DegronMD

Uniprot ID: Q92545

Source protein: Transmembrane protein 131

Source gene: TMEM131

Class: DEG_SCF_FBW7_1

Location: 1818:1825

E3 ligase: FBXW7

DEGRON score: 0.9527

ASA_SCORE: 80.8125

COIL: 0.8709

CONS_SCORE: 0.3602

DSS_SCORE: 0.3091

HELIX: 0.0991

FCONS_SCORE: 1.1015

RIG_SCORE: 0.7509

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1830D	TCGA-FI-A2D0	UCEC	TCGA	PFTTPANT	DEG_SCF_FBW7_1	0.1944
p.G1830D	DO43891	UCEC	ICGC	PFTTPANT	DEG_SCF_FBW7_1	0.1944
p.A1816V	TCGA-IB-7651	PAAD	TCGA	PFTTPANT	DEG_SCF_FBW7_1	0.2778
p.A1816V	DO46657	PAAD	ICGC	PFTTPANT	DEG_SCF_FBW7_1	0.2778
p.A1816T	DO230342	COCA	ICGC	PFTTPANT	DEG_SCF_FBW7_1	0.2778
p.A1816T	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PFTTPANT	DEG_SCF_FBW7_1	0.2778
p.A1816T	ACH-000937	Leukemia	CCLE	PFTTPANT	DEG_SCF_FBW7_1	0.2778
p.A1816T	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PFTTPANT	DEG_SCF_FBW7_1	0.2778
p.T1825M	DO227646	COCA	ICGC	PFTTPANT	DEG_SCF_FBW7_1	0.7423
p.S1815G	DO233168	GACA	ICGC	PFTTPANT	DEG_SCF_FBW7_1	0.25
p.S1828R	DO229029	LICA	ICGC	PFTTPANT	DEG_SCF_FBW7_1	0.25
p.G1830S	SIDM01113	Other Sarcomas	GDSC	PFTTPANT	DEG_SCF_FBW7_1	0.1944
p.G1830S	ACH-000939	Sarcoma	CCLE	PFTTPANT	DEG_SCF_FBW7_1	0.1944
p.G1830S	SK-UT-1	soft_tissue	COSMIC	PFTTPANT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92545	Transmembrane protein 131	DEG_SCF_FBW7_1	1818:1825	PFTTPANT	FBXW7	0.9527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons