DegronMD

Uniprot ID: P01130

Source protein: Low-density lipoprotein receptor

Source gene: LDLR

Class: DEG_SCF_FBW7_1

Location: 753:760

E3 ligase: FBXW7

DEGRON score: 0.9779

ASA_SCORE: 46.5625

COIL: 0.8535

CONS_SCORE: 0.56

DSS_SCORE: 0.5732

HELIX: 0.0433

FCONS_SCORE: 1.0723

RIG_SCORE: 0.6809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R744Q	TCGA-AX-A2HC	UCEC	TCGA	PGATPGLT	DEG_SCF_FBW7_1	0.0833
p.S768F	TCGA-EB-A44O	SKCM	TCGA	PGATPGLT	DEG_SCF_FBW7_1	0.1111
p.T761R	SIDM00382	Glioblastoma	GDSC	PGATPGLT	DEG_SCF_FBW7_1	0.3056
p.T761R	ACH-000609	Brain Cancer	CCLE	PGATPGLT	DEG_SCF_FBW7_1	0.3056
p.T761R	SF126	central_nervous_system	COSMIC	PGATPGLT	DEG_SCF_FBW7_1	0.3056
p.G764R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PGATPGLT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01130	Low-density lipoprotein receptor	DEG_SCF_FBW7_1	753:760	PGATPGLT	FBXW7	0.9779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons