DegronMD

Uniprot ID: Q8WUZ0

Source protein: B-cell CLL/lymphoma 7 protein family member C

Source gene: BCL7C

Class: DEG_SCF_FBW7_1

Location: 115:122

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 92.2625

COIL: 0.9751

CONS_SCORE: 0.5344

DSS_SCORE: 0.9065

HELIX: 0.0106

FCONS_SCORE: 1.0439

RIG_SCORE: 0.4286

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S106F	TCGA-EE-A29M	SKCM	TCGA	PGGTPQPS	DEG_SCF_FBW7_1	0.5278
p.S106F	DO37404	SKCM	ICGC	PGGTPQPS	DEG_SCF_FBW7_1	0.5278
p.P119T	TCGA-EE-A3AA	SKCM	TCGA	PGGTPQPS	DEG_SCF_FBW7_1	0.7031
p.P119T	DO37571	SKCM	ICGC	PGGTPQPS	DEG_SCF_FBW7_1	0.7031
p.G117S	DO222662	MELA	ICGC	PGGTPQPS	DEG_SCF_FBW7_1	0.5882
p.G105S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PGGTPQPS	DEG_SCF_FBW7_1	0.0556
p.G105S	ACH-000995	Leukemia	CCLE	PGGTPQPS	DEG_SCF_FBW7_1	0.0556
p.G105S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PGGTPQPS	DEG_SCF_FBW7_1	0.0556
p.R123H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PGGTPQPS	DEG_SCF_FBW7_1	0.3056
p.R123H	SIDM00534	Colorectal Carcinoma	GDSC	PGGTPQPS	DEG_SCF_FBW7_1	0.3056
p.R123H	ACH-000986	Colon/Colorectal Cancer	CCLE	PGGTPQPS	DEG_SCF_FBW7_1	0.3056
p.R123H	ACH-001669	Leukemia	CCLE	PGGTPQPS	DEG_SCF_FBW7_1	0.3056
p.R123H	ACH-002238	Leukemia	CCLE	PGGTPQPS	DEG_SCF_FBW7_1	0.3056
p.R123H	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PGGTPQPS	DEG_SCF_FBW7_1	0.3056
p.R123H	HT-115	large_intestine	COSMIC	PGGTPQPS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUZ0	B-cell CLL/lymphoma 7 protein family member C	DEG_SCF_FBW7_1	115:122	PGGTPQPS	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons