DegronMD - Q8WUZ0(BCL7C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E179K	TCGA-A5-A2K5	UCEC	TCGA	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.1389
p.E179K	TCGA-R5-A7ZI	STAD	TCGA	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.1389
p.E179K	DO222342	STAD	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.1389
p.E179K	DO41379	UCEC	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.1389
p.E159K	TCGA-BG-A221	UCEC	TCGA	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.1944
p.E159K	TCGA-BS-A0UV	UCEC	TCGA	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.1944
p.E159K	DO42384	UCEC	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.1944
p.E159K	DO42793	UCEC	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.1944
p.P170L	TCGA-BK-A13B	UCEC	TCGA	TKEEPVPEL	DEG_COP1_1	164:172	Mutation altering degron motif	0.7582
p.P170L	DO40825	UCEC	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation altering degron motif	0.7582
p.A154T	TCGA-CK-4951	COAD	TCGA	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.0556
p.A154T	DO10582	COAD	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.0556
p.S106F	TCGA-EE-A29M	SKCM	TCGA	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation blocking phosphorylation signal	0.5278
p.S106F	DO37404	SKCM	ICGC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation blocking phosphorylation signal	0.5278
p.P119T	TCGA-EE-A3AA	SKCM	TCGA	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.7031
p.P119T	DO37571	SKCM	ICGC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.7031
p.P161T	TCGA-X7-A8DF	THYM	TCGA	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.25
p.P168S	DO222973	BTCA	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation altering degron motif	0.5641
p.P170A	DO222744	ESCA	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation altering degron motif	0.7503
p.P160S	DO218693	GACA	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.2222
p.P160H	DO229041	LICA	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.2222
p.L163M	DO229045	LICA	ICGC	TKEEPVPEL	DEG_COP1_1	164:172	Mutation rewiring degron network	0.3056
p.G117S	DO222662	MELA	ICGC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.5882
p.G105S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.0556
p.G105S	ACH-000995	Leukemia	CCLE	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.0556
p.G105S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.0556
p.R123H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.R123H	SIDM00534	Colorectal Carcinoma	GDSC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.R123H	ACH-000986	Colon/Colorectal Cancer	CCLE	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.R123H	ACH-001669	Leukemia	CCLE	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.R123H	ACH-002238	Leukemia	CCLE	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.R123H	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.R123H	HT-115	large intestine	COSMIC	PGGTPQPS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056

Kaplan plot for BCL7C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCL7C

UniProt ID: Q8WUZ0

Entrez ID: 9274

Protein name: B-cell CLL/lymphoma 7 protein family member C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCL7C in