DegronMD

Uniprot ID: Q8WUZ0

Source protein: B-cell CLL/lymphoma 7 protein family member C

Source gene: BCL7C

Class: DEG_COP1_1

Location: 164:172

E3 ligase: COP1

DEGRON score: 0.9892

ASA_SCORE: 103.9667

COIL: 0.8133

CONS_SCORE: 0.5179

DSS_SCORE: 0.7678

HELIX: 0.1539

FCONS_SCORE: 1.0276

RIG_SCORE: 0.7161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E179K	TCGA-A5-A2K5	UCEC	TCGA	TKEEPVPEL	DEG_COP1_1	0.1389
p.E179K	TCGA-R5-A7ZI	STAD	TCGA	TKEEPVPEL	DEG_COP1_1	0.1389
p.E179K	DO222342	STAD	ICGC	TKEEPVPEL	DEG_COP1_1	0.1389
p.E179K	DO41379	UCEC	ICGC	TKEEPVPEL	DEG_COP1_1	0.1389
p.E159K	TCGA-BG-A221	UCEC	TCGA	TKEEPVPEL	DEG_COP1_1	0.1944
p.E159K	TCGA-BS-A0UV	UCEC	TCGA	TKEEPVPEL	DEG_COP1_1	0.1944
p.E159K	DO42384	UCEC	ICGC	TKEEPVPEL	DEG_COP1_1	0.1944
p.E159K	DO42793	UCEC	ICGC	TKEEPVPEL	DEG_COP1_1	0.1944
p.P170L	TCGA-BK-A13B	UCEC	TCGA	TKEEPVPEL	DEG_COP1_1	0.7582
p.P170L	DO40825	UCEC	ICGC	TKEEPVPEL	DEG_COP1_1	0.7582
p.A154T	TCGA-CK-4951	COAD	TCGA	TKEEPVPEL	DEG_COP1_1	0.0556
p.A154T	DO10582	COAD	ICGC	TKEEPVPEL	DEG_COP1_1	0.0556
p.P161T	TCGA-X7-A8DF	THYM	TCGA	TKEEPVPEL	DEG_COP1_1	0.25
p.P168S	DO222973	BTCA	ICGC	TKEEPVPEL	DEG_COP1_1	0.5641
p.P170A	DO222744	ESCA	ICGC	TKEEPVPEL	DEG_COP1_1	0.7503
p.P160S	DO218693	GACA	ICGC	TKEEPVPEL	DEG_COP1_1	0.2222
p.P160H	DO229041	LICA	ICGC	TKEEPVPEL	DEG_COP1_1	0.2222
p.L163M	DO229045	LICA	ICGC	TKEEPVPEL	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUZ0	B-cell CLL/lymphoma 7 protein family member C	DEG_COP1_1	164:172	TKEEPVPEL	COP1	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons