DegronMD

Uniprot ID: P17024

Source protein: Zinc finger protein 20

Source gene: ZNF20

Class: DEG_SCF_FBW7_1

Location: 100:107

E3 ligase: FBXW7

DEGRON score: 0.9568

ASA_SCORE: 62.85

COIL: 0.6846

CONS_SCORE: 0.5355

DSS_SCORE: 0.3459

HELIX: 0.0629

FCONS_SCORE: 1.4135

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R110H	DO234202	ESAD	ICGC	PGITPCES	DEG_SCF_FBW7_1	0.25
p.T115M	SIDM00773	Non-Cancerous	GDSC	PGITPCES	DEG_SCF_FBW7_1	0.1111
p.T115M	SIDM00774	Breast Carcinoma	GDSC	PGITPCES	DEG_SCF_FBW7_1	0.1111
p.G116R	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PGITPCES	DEG_SCF_FBW7_1	0.0833
p.G116R	ACH-000432	Leukemia	CCLE	PGITPCES	DEG_SCF_FBW7_1	0.0833
p.G116R	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PGITPCES	DEG_SCF_FBW7_1	0.0833
p.D92G	SIDM00980	Gastric Carcinoma	GDSC	PGITPCES	DEG_SCF_FBW7_1	0.1111
p.D92G	ACH-000948	Gastric Cancer	CCLE	PGITPCES	DEG_SCF_FBW7_1	0.1111
p.D92G	23132-87	stomach	COSMIC	PGITPCES	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17024	Zinc finger protein 20	DEG_SCF_FBW7_1	100:107	PGITPCES	FBXW7	0.9568	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons