DegronMD - P17024(ZNF20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R64I	TCGA-AG-A002	READ	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.6991
p.I55V	TCGA-AX-A2HJ	UCEC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55V	DO42105	UCEC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.R70K	TCGA-CV-7261	HNSC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.6126
p.R70K	DO15062	HNSC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.6126
p.S76I	TCGA-EI-6917	READ	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1667
p.S76I	DO36881	READ	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1667
p.E58K	TCGA-EK-A3GJ	CESC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.2222
p.M69I	TCGA-G3-AAV0	LIHC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.6507
p.M69I	DO52294	LIHC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.6507
p.I55T	TCGA-LP-A7HU	CESC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55T	DO51611	CESC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.E55K	DO49962	CESC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.R110H	DO234202	ESAD	ICGC	NRKTLPGIT	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.1389
p.R110H	DO234202	ESAD	ICGC	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.25
p.T115M	SIDM00773	Non-Cancerous	GDSC	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.1111
p.T115M	SIDM00774	Breast Carcinoma	GDSC	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.1111
p.G116R	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.0833
p.G116R	ACH-000432	Leukemia	CCLE	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.0833
p.G116R	BV-173	haematopoietic and lymphoid tissue	COSMIC	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.0833
p.D92G	SIDM00980	Gastric Carcinoma	GDSC	NRKTLPGIT	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.25
p.D92G	SIDM00980	Gastric Carcinoma	GDSC	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.1111
p.D92G	ACH-000948	Gastric Cancer	CCLE	NRKTLPGIT	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.25
p.D92G	ACH-000948	Gastric Cancer	CCLE	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.1111
p.D92G	23132-87	stomach	COSMIC	NRKTLPGIT	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.25
p.D92G	23132-87	stomach	COSMIC	PGITPCES	DEG_SCF_FBW7_1	100:107	Mutation rewiring degron network	0.1111

Kaplan plot for ZNF20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF20

UniProt ID: P17024

Entrez ID: 7568

Protein name: Zinc finger protein 20 (Zinc finger protein KOX13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF20 in