DegronMD

Uniprot ID: P17024

Source protein: Zinc finger protein 20

Source gene: ZNF20

Class: DEG_APCC_DBOX_1

Location: 62:70

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9368

ASA_SCORE: 111.5222

COIL: 0.6776

CONS_SCORE: 0.4221

DSS_SCORE: 0.3937

HELIX: 0.1163

FCONS_SCORE: 1.0826

RIG_SCORE: 0.7819

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R64I	TCGA-AG-A002	READ	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	0.6991
p.I55V	TCGA-AX-A2HJ	UCEC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	0.1389
p.I55V	DO42105	UCEC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	0.1389
p.R70K	TCGA-CV-7261	HNSC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	0.6126
p.R70K	DO15062	HNSC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	0.6126
p.S76I	TCGA-EI-6917	READ	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	0.1667
p.S76I	DO36881	READ	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	0.1667
p.E58K	TCGA-EK-A3GJ	CESC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	0.2222
p.M69I	TCGA-G3-AAV0	LIHC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	0.6507
p.M69I	DO52294	LIHC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	0.6507
p.I55T	TCGA-LP-A7HU	CESC	TCGA	PRRNLSLMR	DEG_APCC_DBOX_1	0.1389
p.I55T	DO51611	CESC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	0.1389
p.E55K	DO49962	CESC	ICGC	PRRNLSLMR	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17024	Zinc finger protein 20	DEG_APCC_DBOX_1	62:70	PRRNLSLMR	APC,CDC20,FZR1	0.9368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons