DegronMD

Uniprot ID: Q9H869

Source protein: YY1-associated protein 1

Source gene: YY1AP1

Class: DEG_SCF_FBW7_1

Location: 475:482

E3 ligase: FBXW7

DEGRON score: 0.9887

ASA_SCORE: 82.2

COIL: 0.937

CONS_SCORE: 0.6774

DSS_SCORE: 0.7653

HELIX: 0.0221

FCONS_SCORE: 0.9995

RIG_SCORE: 0.5353

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R481W	TCGA-06-5416	GBM	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.8634
p.R481W	TCGA-B5-A1MW	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.8634
p.R481W	TCGA-D1-A177	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.8634
p.E479K	TCGA-55-8208	LUAD	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.7022
p.R481Q	TCGA-66-2758	LUSC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.7329
p.R481Q	SIDM00057	Neuroblastoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	0.7329
p.R481Q	SIDM00552	Rhabdomyosarcoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	0.7329
p.R481Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	0.7329
p.R481Q	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	0.7329
p.R481Q	SIDM01559	Melanoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	0.7329
p.L473M	TCGA-AP-A1DV	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.2778
p.D485N	TCGA-AX-A1CA	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.25
p.L465F	TCGA-B5-A3FC	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.0556
p.E478V	TCGA-BP-5191	KIRC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.7693
p.P466S	TCGA-D8-A1XK	BRCA	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.5278
p.E478D	TCGA-EO-A3B0	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.6758
p.A487V	TCGA-EY-A1GU	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	0.1944
p.A481V	DO222769	COCA	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	0.6936
p.T477S	DO233923	GACA	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	0.7116
p.S478Y	DO229027	LICA	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	0.712
p.V487A	DO37861	SKCM	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	0.1944
p.R489I	DO39421	THCA	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	0.1389
p.G484S	DO43073	UCEC	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	0.2778
p.P468S	DO43250	UCEC	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	0.1389
p.D465N	DO42873	UCEC	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	0.0556
p.M475I	NCI-H128	lung	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	0.7618
p.I479S	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	0.7341
p.R491Q	A204	soft_tissue	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	0.5278
p.M466I	NCI-H128	lung	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	0.5278
p.M486I	NCI-H128	lung	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGKTPAQS

Degron related mutations and impact score

Drug responses associated with YY1AP1 mutations

All proteins holding degron of PGKTPAQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H869	YY1-associated protein 1	DEG_SCF_FBW7_1	475:482	PGKTPAQS	FBXW7	0.9887	More...