DegronMD

Uniprot ID: Q14031

Source protein: Collagen alpha-6

Source gene: COL4A6

Class: DEG_SCF_FBW7_2

Location: 1366:1373

E3 ligase: FBXW7

DEGRON score: 0.9093

ASA_SCORE: 78.2625

COIL: 0.8871

CONS_SCORE: 0.3403

DSS_SCORE: 0.817

HELIX: 0.0806

FCONS_SCORE: 0.7524

RIG_SCORE: 0.6238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1364D	TCGA-85-7710	LUSC	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	0.2778
p.Q1363H	TCGA-AX-A2HC	UCEC	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	0.25
p.S1359C	TCGA-D7-A6EY	STAD	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	0.1389
p.P1378L	TCGA-DI-A1BU	UCEC	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	0.1944
p.P1378L	DO42023	UCEC	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.1944
p.Q1376K	TCGA-EE-A184	SKCM	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	0.25
p.D1363Y	DO224781	BRCA	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.25
p.D1363Y	DO52544	BRCA	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.25
p.G1376S	DO10228	COAD	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.25
p.S1383P	DO52674	MALY	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.0556
p.P1366H	DO51407	PRAD	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.7694
p.P1366H	DO229211	THCA	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.7694
p.G1367D	DO47789	STAD	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.6087
p.P1372S	DO42568	UCEC	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	0.6752
p.M1366I	SIDM00075	Non-Cancerous	GDSC	PGQTPTAE	DEG_SCF_FBW7_2	0.7618
p.P1369L	ACH-000951	Lung Cancer	CCLE	PGQTPTAE	DEG_SCF_FBW7_2	0.7582
p.P1369L	NCI-H2342	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.7582
p.V1376F	ACH-000973	Bladder Cancer	CCLE	PGQTPTAE	DEG_SCF_FBW7_2	0.25
p.V1376F	639-V	urinary_tract	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.25
p.P1372Q	NCI-H2081	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.7035
p.V1377F	639-V	urinary_tract	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.2222
p.P1370L	NCI-H2342	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.7582
p.P1360Q	NCI-H2081	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.1667
p.P1362L	NCI-H2342	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.2222
p.V1364F	639-V	urinary_tract	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.2778
p.P1357L	NCI-H2342	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14031	Collagen alpha-6	DEG_SCF_FBW7_2	1366:1373	PGQTPTAE	FBXW7	0.9093	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGQTPTAE

Degron related mutations and impact score

Drug responses associated with COL4A6 mutations

All proteins holding degron of PGQTPTAE