DegronMD - Q14031(COL4A6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1364D	TCGA-85-7710	LUSC	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.2778
p.G807E	TCGA-94-8035	LUSC	TCGA	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.1944
p.Q1363H	TCGA-AX-A2HC	UCEC	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.25
p.P815Q	TCGA-CN-6010	HNSC	TCGA	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation altering degron motif	0.7035
p.P815Q	DO14766	HNSC	ICGC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation altering degron motif	0.7035
p.P812Q	TCGA-D3-A1Q1	SKCM	TCGA	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation altering degron motif	0.7035
p.P812Q	DO37445	SKCM	ICGC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation altering degron motif	0.7035
p.S1359C	TCGA-D7-A6EY	STAD	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.1389
p.P1378L	TCGA-DI-A1BU	UCEC	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.1944
p.P1378L	DO42023	UCEC	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.1944
p.Q1376K	TCGA-EE-A184	SKCM	TCGA	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.25
p.P820Q	TCGA-EE-A20F	SKCM	TCGA	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.2778
p.P820Q	TCGA-EE-A3AG	SKCM	TCGA	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.2778
p.D1363Y	DO224781	BRCA	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.25
p.D1363Y	DO52544	BRCA	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.25
p.G1376S	DO10228	COAD	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.25
p.Q807K	DO229031	LICA	ICGC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.1944
p.G806E	DO219173	LUSC	ICGC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.1667
p.S1383P	DO52674	MALY	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.0556
p.G803E	DO222699	MELA	ICGC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.0833
p.S817F	DO232224	PBCA	ICGC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation altering degron motif	0.6871
p.P1366H	DO51407	PRAD	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.7694
p.P1366H	DO229211	THCA	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.7694
p.P819Q	DO37471	SKCM	ICGC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.3056
p.P819Q	DO37961	SKCM	ICGC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.3056
p.G1367D	DO47789	STAD	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.6087
p.P1372S	DO42568	UCEC	ICGC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.6752
p.G808S	SIDM00253	Neuroblastoma	GDSC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.2222
p.G808S	SIDM01206	Neuroblastoma	GDSC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.2222
p.G808S	SIDM01132	Other Solid Cancers	GDSC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.2222
p.G808S	SIDM01052	Ovarian Carcinoma	GDSC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.2222
p.M1366I	SIDM00075	Non-Cancerous	GDSC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.7618
p.P1369L	ACH-000951	Lung Cancer	CCLE	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.7582
p.P1369L	NCI-H2342	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.7582
p.G821D	ACH-000971	Colon/Colorectal Cancer	CCLE	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.25
p.G821D	HCT-116	large intestine	COSMIC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.25
p.V1376F	ACH-000973	Bladder Cancer	CCLE	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.25
p.V1376F	639-V	urinary tract	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.25
p.G824D	ACH-001638	Lymphoma	CCLE	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation substituting flanking lysine	0.2778
p.G824D	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation substituting flanking lysine	0.2778
p.P1372Q	NCI-H2081	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.7035
p.V1377F	639-V	urinary tract	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.2222
p.P1370L	NCI-H2342	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation altering degron motif	0.7582
p.G822D	HCT-116	large intestine	COSMIC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.2222
p.G825D	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PGTPGSS	DEG_SCF_FBW7_1	812:818	Mutation rewiring degron network	0.1389
p.P1360Q	NCI-H2081	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.1667
p.P1362L	NCI-H2342	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.2222
p.V1364F	639-V	urinary tract	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.2778
p.P1357L	NCI-H2342	lung	COSMIC	PGQTPTAE	DEG_SCF_FBW7_2	1366:1373	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL4A6

UniProt ID: Q14031

Entrez ID: 1288

Protein name: Collagen alpha-6(IV) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL4A6 in