DegronMD

Uniprot ID: Q14031

Source protein: Collagen alpha-6

Source gene: COL4A6

Class: DEG_SCF_FBW7_1

Location: 812:818

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 67.9143

COIL: 0.9451

CONS_SCORE: 0.4946

DSS_SCORE: 0.766

HELIX: 0.0114

FCONS_SCORE: 1.2068

RIG_SCORE: 0.5227

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G807E	TCGA-94-8035	LUSC	TCGA	PGTPGSS	DEG_SCF_FBW7_1	0.1944
p.P815Q	TCGA-CN-6010	HNSC	TCGA	PGTPGSS	DEG_SCF_FBW7_1	0.7035
p.P815Q	DO14766	HNSC	ICGC	PGTPGSS	DEG_SCF_FBW7_1	0.7035
p.P812Q	TCGA-D3-A1Q1	SKCM	TCGA	PGTPGSS	DEG_SCF_FBW7_1	0.7035
p.P812Q	DO37445	SKCM	ICGC	PGTPGSS	DEG_SCF_FBW7_1	0.7035
p.P820Q	TCGA-EE-A20F	SKCM	TCGA	PGTPGSS	DEG_SCF_FBW7_1	0.2778
p.P820Q	TCGA-EE-A3AG	SKCM	TCGA	PGTPGSS	DEG_SCF_FBW7_1	0.2778
p.Q807K	DO229031	LICA	ICGC	PGTPGSS	DEG_SCF_FBW7_1	0.1944
p.G806E	DO219173	LUSC	ICGC	PGTPGSS	DEG_SCF_FBW7_1	0.1667
p.G803E	DO222699	MELA	ICGC	PGTPGSS	DEG_SCF_FBW7_1	0.0833
p.S817F	DO232224	PBCA	ICGC	PGTPGSS	DEG_SCF_FBW7_1	0.6871
p.P819Q	DO37471	SKCM	ICGC	PGTPGSS	DEG_SCF_FBW7_1	0.3056
p.P819Q	DO37961	SKCM	ICGC	PGTPGSS	DEG_SCF_FBW7_1	0.3056
p.G808S	SIDM00253	Neuroblastoma	GDSC	PGTPGSS	DEG_SCF_FBW7_1	0.2222
p.G808S	SIDM01206	Neuroblastoma	GDSC	PGTPGSS	DEG_SCF_FBW7_1	0.2222
p.G808S	SIDM01132	Other Solid Cancers	GDSC	PGTPGSS	DEG_SCF_FBW7_1	0.2222
p.G808S	SIDM01052	Ovarian Carcinoma	GDSC	PGTPGSS	DEG_SCF_FBW7_1	0.2222
p.G821D	ACH-000971	Colon/Colorectal Cancer	CCLE	PGTPGSS	DEG_SCF_FBW7_1	0.25
p.G821D	HCT-116	large_intestine	COSMIC	PGTPGSS	DEG_SCF_FBW7_1	0.25
p.G824D	ACH-001638	Lymphoma	CCLE	PGTPGSS	DEG_SCF_FBW7_1	0.2778
p.G824D	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPGSS	DEG_SCF_FBW7_1	0.2778
p.G822D	HCT-116	large_intestine	COSMIC	PGTPGSS	DEG_SCF_FBW7_1	0.2222
p.G825D	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPGSS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14031	Collagen alpha-6	DEG_SCF_FBW7_1	812:818	PGTPGSS	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons