DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 8207:8214

E3 ligase: FBXW7

DEGRON score: 0.5505

ASA_SCORE: 91.1375

COIL: 0.9348

CONS_SCORE: 0

DSS_SCORE: 0.7342

HELIX: 0.0164

FCONS_SCORE: 0

RIG_SCORE: 0.5687

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E8212K	TCGA-62-A46O	LUAD	TCGA	PGSTPEST	DEG_SCF_FBW7_1	0.591
p.E8212K	DO26240	LUAD	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.591
p.G8208W	TCGA-95-7562	LUAD	TCGA	PGSTPEST	DEG_SCF_FBW7_1	0.6714
p.G8208W	DO51196	LUAD	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.6714
p.P8223S	TCGA-CD-8536	STAD	TCGA	PGSTPEST	DEG_SCF_FBW7_1	0.0833
p.P8223S	DO218874	SKCA	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.0833
p.P8223S	DO47827	STAD	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.0833
p.T8204A	TCGA-CN-A497	HNSC	TCGA	PGSTPEST	DEG_SCF_FBW7_1	0.25
p.T8204A	DO218992	HNSC	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.25
p.T8216A	TCGA-EO-A22R	UCEC	TCGA	PGSTPEST	DEG_SCF_FBW7_1	0.2778
p.T8216A	DO230940	LUSC	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.2778
p.T8216A	DO224584	LUSC	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.2778
p.T8216A	DO42713	UCEC	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.2778
p.D8205N	TCGA-FS-A1ZK	SKCM	TCGA	PGSTPEST	DEG_SCF_FBW7_1	0.2778
p.D8205N	DO37474	SKCM	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.2778
p.V8217M	DO230343	COCA	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.25
p.I8200T	DO227999	COCA	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.1389
p.I8200T	DO229003	COCA	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.1389
p.I8200T	DO230659	LAML	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.1389
p.I8200T	DO231140	LAML	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.1389
p.G8208A	DO45151	LIRI	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.6429
p.P8206S	DO222647	MELA	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.3056
p.T8221R	DO50687	ORCA	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.1389
p.S8220L	DO229456	SKCA	ICGC	PGSTPEST	DEG_SCF_FBW7_1	0.1667
p.P8206H	SIDM00216	Colorectal Carcinoma	GDSC	PGSTPEST	DEG_SCF_FBW7_1	0.3056
p.P8206H	ACH-000989	Colon/Colorectal Cancer	CCLE	PGSTPEST	DEG_SCF_FBW7_1	0.3056
p.P8206H	SNU-175	large_intestine	COSMIC	PGSTPEST	DEG_SCF_FBW7_1	0.3056
p.T8214I	SIDM00572	Gastric Carcinoma	GDSC	PGSTPEST	DEG_SCF_FBW7_1	0.7078
p.T8214I	NUGC-3	stomach	COSMIC	PGSTPEST	DEG_SCF_FBW7_1	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTPEST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PGSTPEST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	8207:8214	PGSTPEST	FBXW7	0.5505	More...