DegronMD

Uniprot ID: O14798

Source protein: Tumor necrosis factor receptor superfamily member 10C

Source gene: TNFRSF10C

Class: DEG_SCF_FBW7_1

Location: 232:238

E3 ligase: FBXW7

DEGRON score: 0.6589

ASA_SCORE: 48.7714

COIL: 0.7861

CONS_SCORE: 0.5038

DSS_SCORE: 0.2859

HELIX: 0.1436

FCONS_SCORE: 0.9969

RIG_SCORE: 0.6949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A223T	TCGA-56-8628	LUSC	TCGA	PGTPASS	DEG_SCF_FBW7_1	0.0833
p.M228I	TCGA-A5-A0G1	UCEC	TCGA	PGTPASS	DEG_SCF_FBW7_1	0.2222
p.S231I	TCGA-A5-A0G1	UCEC	TCGA	PGTPASS	DEG_SCF_FBW7_1	0.3056
p.P235L	TCGA-DD-AAVR	LIHC	TCGA	PGTPASS	DEG_SCF_FBW7_1	0.7582
p.S238Y	TCGA-EO-A3B0	UCEC	TCGA	PGTPASS	DEG_SCF_FBW7_1	0.712
p.C243Y	TCGA-XK-AAIW	PRAD	TCGA	PGTPASS	DEG_SCF_FBW7_1	0.1944
p.G233R	ACH-000036	Brain Cancer	CCLE	PGTPASS	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14798	Tumor necrosis factor receptor superfamily member 10C	DEG_SCF_FBW7_1	232:238	PGTPASS	FBXW7	0.6589	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons