DegronMD

Uniprot ID: Q5JR12

Source protein: Protein phosphatase 1J

Source gene: PPM1J

Class: DEG_SCF_FBW7_1

Location: 202:208

E3 ligase: FBXW7

DEGRON score: 0.649

ASA_SCORE: 67.4571

COIL: 0.9157

CONS_SCORE: 0.3237

DSS_SCORE: 0.6767

HELIX: 0.0583

FCONS_SCORE: 0.9625

RIG_SCORE: 0.5539

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L213V	TCGA-AP-A056	UCEC	TCGA	PGTPDSS	DEG_SCF_FBW7_1	0.1944
p.L213V	DO43971	UCEC	ICGC	PGTPDSS	DEG_SCF_FBW7_1	0.1944
p.P202Q	DO222856	COCA	ICGC	PGTPDSS	DEG_SCF_FBW7_1	0.7035
p.P202Q	SIDM02021	Esophageal Carcinoma	GDSC	PGTPDSS	DEG_SCF_FBW7_1	0.7035
p.P193L	DO228585	LICA	ICGC	PGTPDSS	DEG_SCF_FBW7_1	0.0833
p.P202S	DO220881	MELA	ICGC	PGTPDSS	DEG_SCF_FBW7_1	0.6752
p.S218P	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PGTPDSS	DEG_SCF_FBW7_1	0.0556
p.S218P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PGTPDSS	DEG_SCF_FBW7_1	0.0556
p.S218P	ACH-000995	Leukemia	CCLE	PGTPDSS	DEG_SCF_FBW7_1	0.0556
p.S218P	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPDSS	DEG_SCF_FBW7_1	0.0556
p.P216H	ACH-001610	Brain Cancer	CCLE	PGTPDSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JR12	Protein phosphatase 1J	DEG_SCF_FBW7_1	202:208	PGTPDSS	FBXW7	0.649	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons