DegronMD

Uniprot ID: Q8IVT2

Source protein: Mitotic interactor and substrate of PLK1

Source gene: MISP

Class: DEG_SCF_FBW7_1

Location: 285:291

E3 ligase: FBXW7

DEGRON score: 0.9407

ASA_SCORE: 93.5714

COIL: 0.9507

CONS_SCORE: 0.5658

DSS_SCORE: 0.6474

HELIX: 0.0247

FCONS_SCORE: 0.9786

RIG_SCORE: 0.6132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R295Q	TCGA-A6-6781	COAD	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.2222
p.R295Q	DO8447	COAD	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.2222
p.R298H	TCGA-AX-A2IN	UCEC	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.1389
p.R298H	TCGA-EB-A51B	SKCM	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.1389
p.R298H	TCGA-F7-A624	HNSC	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.1389
p.R298H	DO44440	HNSC	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.1389
p.R298H	DO47343	SKCM	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.1389
p.R298H	DO42328	UCEC	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.1389
p.T287I	TCGA-B0-4827	KIRC	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.8189
p.T287I	DO16158	KIRC	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.8189
p.R295W	TCGA-B5-A11H	UCEC	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.2222
p.R295W	DO42825	UCEC	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.2222
p.D275N	TCGA-CK-4951	COAD	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.0556
p.D275N	DO10582	COAD	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.0556
p.E294K	TCGA-FW-A3R5	SKCM	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.25
p.E294K	DO37406	SKCM	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.25
p.S281L	TCGA-ZF-A9R7	BLCA	TCGA	PGTPKET	DEG_SCF_FBW7_1	0.6667
p.S281L	DO219064	BLCA	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.6667
p.R298C	DO233653	GACA	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.1389
p.V282L	DO229031	LICA	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.25
p.R295L	DO50680	ORCA	ICGC	PGTPKET	DEG_SCF_FBW7_1	0.2222
p.V282A	SIDM01617	Endometrial Carcinoma	GDSC	PGTPKET	DEG_SCF_FBW7_1	0.25
p.V282A	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGTPKET	DEG_SCF_FBW7_1	0.25
p.P288S	ACH-000773	Lymphoma	CCLE	PGTPKET	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVT2	Mitotic interactor and substrate of PLK1	DEG_SCF_FBW7_1	285:291	PGTPKET	FBXW7	0.9407	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons