DegronMD - Q8IVT2(MISP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G174S	TCGA-71-8520	LUAD	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.2778
p.G174S	DO48882	LUAD	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.2778
p.R177Q	TCGA-76-6657	GBM	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation altering degron motif	0.6218
p.R177Q	DO230342	COCA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation altering degron motif	0.6218
p.R177Q	DO11154	GBM	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation altering degron motif	0.6218
p.P421S	TCGA-90-A4ED	LUSC	TCGA	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.0556
p.P421S	DO45482	LUSC	ICGC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.0556
p.P421L	TCGA-90-A4ED	LUSC	TCGA	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.0556
p.P421L	DO45482	LUSC	ICGC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.0556
p.R295Q	TCGA-A6-6781	COAD	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.2222
p.R295Q	DO8447	COAD	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.2222
p.N581S	TCGA-AP-A054	UCEC	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.0833
p.N581S	DO42256	UCEC	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.0833
p.P329L	TCGA-AX-A2HC	UCEC	TCGA	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.6471
p.P329L	DO41572	UCEC	ICGC	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.6471
p.P329L	SIDM00217	Colorectal Carcinoma	GDSC	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.6471
p.R298H	TCGA-AX-A2IN	UCEC	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1389
p.R298H	TCGA-EB-A51B	SKCM	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1389
p.R298H	TCGA-F7-A624	HNSC	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1389
p.R298H	DO44440	HNSC	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1389
p.R298H	DO47343	SKCM	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1389
p.R298H	DO42328	UCEC	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1389
p.T287I	TCGA-B0-4827	KIRC	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation altering degron motif	0.8189
p.T287I	DO16158	KIRC	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation altering degron motif	0.8189
p.R295W	TCGA-B5-A11H	UCEC	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.2222
p.R295W	DO42825	UCEC	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.2222
p.R565Q	TCGA-BR-8591	STAD	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.3056
p.R565Q	DO47973	STAD	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.3056
p.R565Q	SIDM00077	Oral Cavity Carcinoma	GDSC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.3056
p.R565Q	BICR10	upper aerodigestive tract	COSMIC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.3056
p.R557W	TCGA-CG-5723	STAD	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.0833
p.R557W	DO38376	STAD	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.0833
p.D275N	TCGA-CK-4951	COAD	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.0556
p.D275N	DO10582	COAD	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.0556
p.R565W	TCGA-CV-5977	HNSC	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.3056
p.R565W	DO14403	HNSC	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.3056
p.R565W	DO50879	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.3056
p.P422H	TCGA-DW-7840	KIRP	TCGA	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.0833
p.P422H	DO20790	KIRP	ICGC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.0833
p.G168V	TCGA-EA-A3HU	CESC	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1111
p.G168V	DO6320	CESC	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1111
p.P578L	TCGA-EB-A3HV	SKCM	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.1667
p.P578L	DO37647	SKCM	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.1667
p.V186I	TCGA-EE-A17X	SKCM	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.25
p.V186I	DO37931	SKCM	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.25
p.P326S	TCGA-ER-A2NH	SKCM	TCGA	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.3056
p.P326S	DO47683	SKCM	ICGC	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.3056
p.D318N	TCGA-FI-A2D5	UCEC	TCGA	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0833
p.D318N	DO41331	UCEC	ICGC	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0833
p.R557L	TCGA-FS-A1ZG	SKCM	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.0833
p.R557L	DO37523	SKCM	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.0833
p.E294K	TCGA-FW-A3R5	SKCM	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.E294K	DO37406	SKCM	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.T179M	TCGA-HF-A5NB	STAD	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation altering degron motif	0.8534
p.T179M	DO50127	STAD	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation altering degron motif	0.8534
p.T179M	DO41199	UCEC	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation altering degron motif	0.8534
p.S281L	TCGA-ZF-A9R7	BLCA	TCGA	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation blocking phosphorylation signal	0.6667
p.S281L	DO219064	BLCA	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation blocking phosphorylation signal	0.6667
p.P421Q	DO234462	ESAD	ICGC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.0556
p.R298C	DO233653	GACA	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1389
p.A568V	DO228916	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation altering degron motif	0.5825
p.D166Y	DO228952	LICA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.0556
p.R177L	DO228974	LICA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation altering degron motif	0.7316
p.G174V	DO229028	LICA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.2778
p.V573F	DO229031	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.3056
p.V282L	DO229031	LICA	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.E558D	DO229036	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.1111
p.R556L	DO229037	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.0556
p.P170S	DO222702	MELA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1667
p.R295L	DO50680	ORCA	ICGC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.2222
p.Y425S	DO219881	SKCA	ICGC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.1667
p.Y425S	DO218878	SKCA	ICGC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.1667
p.R557Q	SIDM02013	Colorectal Carcinoma	GDSC	RNALFPE	LIG_APCC_ABBAyCdc20_2	566:572	Mutation rewiring degron network	0.0833
p.R188T	SIDM00586	Hepatocellular Carcinoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1944
p.R188T	SIDM00608	Plasma Cell Myeloma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1944
p.R188T	SIDM00535	Chondrosarcoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1944
p.R188T	SIDM00496	Thyroid Gland Carcinoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1944
p.R188T	SIDM00353	Other Sarcomas	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1944
p.R188T	SIDM00779	Colorectal Carcinoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1944
p.R188T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1944
p.A443V	SIDM01037	Breast Carcinoma	GDSC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.1667
p.A443V	SIDM00940	Breast Carcinoma	GDSC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.1667
p.P329S	SIDM00007	Other Solid Cancers	GDSC	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.5641
p.P329S	ACH-001550	Skin Cancer	CCLE	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.5641
p.P329S	MCC13	skin	COSMIC	TRPLLTKLS	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.5641
p.Y428C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation blocking phosphorylation signal	0.6944
p.Y428C	ACH-002256	Leukemia	CCLE	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation blocking phosphorylation signal	0.6944
p.Y428C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation blocking phosphorylation signal	0.6944
p.F438L	SIDM00193	Colorectal Carcinoma	GDSC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.3056
p.F438L	ACH-000991	Colon/Colorectal Cancer	CCLE	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.3056
p.F438L	SNU-81	large intestine	COSMIC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.3056
p.P427L	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.2222
p.P427L	ACH-000809	Esophageal Cancer	CCLE	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.2222
p.P427L	KYSE-410	oesophagus	COSMIC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.2222
p.G442R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.1944
p.G442R	ACH-001738	Leukemia	CCLE	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.1944
p.G442R	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PGTPQLE	DEG_SCF_FBW7_2	431:437	Mutation rewiring degron network	0.1944
p.V282A	SIDM01617	Endometrial Carcinoma	GDSC	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.V282A	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.P288S	ACH-000773	Lymphoma	CCLE	PGTPKET	DEG_SCF_FBW7_1	285:291	Mutation altering degron motif	0.6752
p.Q190H	ACH-001442	Skin Cancer	CCLE	PRSTPLEE	DEG_SCF_FBW7_2	176:183	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MISP

UniProt ID: Q8IVT2

Entrez ID: 126353

Protein name: Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MISP in