DegronMD

Uniprot ID: Q8IVT2

Source protein: Mitotic interactor and substrate of PLK1

Source gene: MISP

Class: DEG_SCF_FBW7_2

Location: 176:183

E3 ligase: FBXW7

DEGRON score: 0.8001

ASA_SCORE: 106

COIL: 0.8925

CONS_SCORE: 0.3927

DSS_SCORE: 0.7896

HELIX: 0.0808

FCONS_SCORE: 0.7997

RIG_SCORE: 0.6304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G174S	TCGA-71-8520	LUAD	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	0.2778
p.G174S	DO48882	LUAD	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.2778
p.R177Q	TCGA-76-6657	GBM	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	0.6218
p.R177Q	DO230342	COCA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.6218
p.R177Q	DO11154	GBM	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.6218
p.G168V	TCGA-EA-A3HU	CESC	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	0.1111
p.G168V	DO6320	CESC	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.1111
p.V186I	TCGA-EE-A17X	SKCM	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	0.25
p.V186I	DO37931	SKCM	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.25
p.T179M	TCGA-HF-A5NB	STAD	TCGA	PRSTPLEE	DEG_SCF_FBW7_2	0.8534
p.T179M	DO50127	STAD	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.8534
p.T179M	DO41199	UCEC	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.8534
p.D166Y	DO228952	LICA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.0556
p.R177L	DO228974	LICA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.7316
p.G174V	DO229028	LICA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.2778
p.P170S	DO222702	MELA	ICGC	PRSTPLEE	DEG_SCF_FBW7_2	0.1667
p.R188T	SIDM00586	Hepatocellular Carcinoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	0.1944
p.R188T	SIDM00608	Plasma Cell Myeloma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	0.1944
p.R188T	SIDM00535	Chondrosarcoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	0.1944
p.R188T	SIDM00496	Thyroid Gland Carcinoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	0.1944
p.R188T	SIDM00353	Other Sarcomas	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	0.1944
p.R188T	SIDM00779	Colorectal Carcinoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	0.1944
p.R188T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PRSTPLEE	DEG_SCF_FBW7_2	0.1944
p.Q190H	ACH-001442	Skin Cancer	CCLE	PRSTPLEE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVT2	Mitotic interactor and substrate of PLK1	DEG_SCF_FBW7_2	176:183	PRSTPLEE	FBXW7	0.8001	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons