DegronMD

Uniprot ID: Q8IVT2

Source protein: Mitotic interactor and substrate of PLK1

Source gene: MISP

Class: DEG_SCF_FBW7_2

Location: 431:437

E3 ligase: FBXW7

DEGRON score: 0.9073

ASA_SCORE: 75.5571

COIL: 0.7547

CONS_SCORE: 0.3617

DSS_SCORE: 0.4273

HELIX: 0.1679

FCONS_SCORE: 0.9371

RIG_SCORE: 0.7102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P421S	TCGA-90-A4ED	LUSC	TCGA	PGTPQLE	DEG_SCF_FBW7_2	0.0556
p.P421S	DO45482	LUSC	ICGC	PGTPQLE	DEG_SCF_FBW7_2	0.0556
p.P421L	TCGA-90-A4ED	LUSC	TCGA	PGTPQLE	DEG_SCF_FBW7_2	0.0556
p.P421L	DO45482	LUSC	ICGC	PGTPQLE	DEG_SCF_FBW7_2	0.0556
p.P422H	TCGA-DW-7840	KIRP	TCGA	PGTPQLE	DEG_SCF_FBW7_2	0.0833
p.P422H	DO20790	KIRP	ICGC	PGTPQLE	DEG_SCF_FBW7_2	0.0833
p.P421Q	DO234462	ESAD	ICGC	PGTPQLE	DEG_SCF_FBW7_2	0.0556
p.Y425S	DO219881	SKCA	ICGC	PGTPQLE	DEG_SCF_FBW7_2	0.1667
p.Y425S	DO218878	SKCA	ICGC	PGTPQLE	DEG_SCF_FBW7_2	0.1667
p.A443V	SIDM01037	Breast Carcinoma	GDSC	PGTPQLE	DEG_SCF_FBW7_2	0.1667
p.A443V	SIDM00940	Breast Carcinoma	GDSC	PGTPQLE	DEG_SCF_FBW7_2	0.1667
p.Y428C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PGTPQLE	DEG_SCF_FBW7_2	0.6944
p.Y428C	ACH-002256	Leukemia	CCLE	PGTPQLE	DEG_SCF_FBW7_2	0.6944
p.Y428C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPQLE	DEG_SCF_FBW7_2	0.6944
p.F438L	SIDM00193	Colorectal Carcinoma	GDSC	PGTPQLE	DEG_SCF_FBW7_2	0.3056
p.F438L	ACH-000991	Colon/Colorectal Cancer	CCLE	PGTPQLE	DEG_SCF_FBW7_2	0.3056
p.F438L	SNU-81	large_intestine	COSMIC	PGTPQLE	DEG_SCF_FBW7_2	0.3056
p.P427L	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PGTPQLE	DEG_SCF_FBW7_2	0.2222
p.P427L	ACH-000809	Esophageal Cancer	CCLE	PGTPQLE	DEG_SCF_FBW7_2	0.2222
p.P427L	KYSE-410	oesophagus	COSMIC	PGTPQLE	DEG_SCF_FBW7_2	0.2222
p.G442R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PGTPQLE	DEG_SCF_FBW7_2	0.1944
p.G442R	ACH-001738	Leukemia	CCLE	PGTPQLE	DEG_SCF_FBW7_2	0.1944
p.G442R	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPQLE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVT2	Mitotic interactor and substrate of PLK1	DEG_SCF_FBW7_2	431:437	PGTPQLE	FBXW7	0.9073	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons