DegronMD

Uniprot ID: Q8IVT2

Source protein: Mitotic interactor and substrate of PLK1

Source gene: MISP

Class: DEG_APCC_DBOX_1

Location: 327:335

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5598

ASA_SCORE: 92.0111

COIL: 0.7978

CONS_SCORE: 0.4769

DSS_SCORE: 0.3466

HELIX: 0.1148

FCONS_SCORE: 0.9221

RIG_SCORE: 0.805

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P329L	TCGA-AX-A2HC	UCEC	TCGA	TRPLLTKLS	DEG_APCC_DBOX_1	0.6471
p.P329L	DO41572	UCEC	ICGC	TRPLLTKLS	DEG_APCC_DBOX_1	0.6471
p.P329L	SIDM00217	Colorectal Carcinoma	GDSC	TRPLLTKLS	DEG_APCC_DBOX_1	0.6471
p.P326S	TCGA-ER-A2NH	SKCM	TCGA	TRPLLTKLS	DEG_APCC_DBOX_1	0.3056
p.P326S	DO47683	SKCM	ICGC	TRPLLTKLS	DEG_APCC_DBOX_1	0.3056
p.D318N	TCGA-FI-A2D5	UCEC	TCGA	TRPLLTKLS	DEG_APCC_DBOX_1	0.0833
p.D318N	DO41331	UCEC	ICGC	TRPLLTKLS	DEG_APCC_DBOX_1	0.0833
p.P329S	SIDM00007	Other Solid Cancers	GDSC	TRPLLTKLS	DEG_APCC_DBOX_1	0.5641
p.P329S	ACH-001550	Skin Cancer	CCLE	TRPLLTKLS	DEG_APCC_DBOX_1	0.5641
p.P329S	MCC13	skin	COSMIC	TRPLLTKLS	DEG_APCC_DBOX_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVT2	Mitotic interactor and substrate of PLK1	DEG_APCC_DBOX_1	327:335	TRPLLTKLS	APC,CDC20,FZR1	0.5598	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons