DegronMD

Uniprot ID: Q8IVT2

Source protein: Mitotic interactor and substrate of PLK1

Source gene: MISP

Class: LIG_APCC_ABBAyCdc20_2

Location: 566:572

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9733

ASA_SCORE: 107.4857

COIL: 0.6449

CONS_SCORE: 0.5303

DSS_SCORE: 0.5938

HELIX: 0.3331

FCONS_SCORE: 1.0447

RIG_SCORE: 0.7208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N581S	TCGA-AP-A054	UCEC	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.N581S	DO42256	UCEC	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R565Q	TCGA-BR-8591	STAD	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R565Q	DO47973	STAD	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R565Q	SIDM00077	Oral Cavity Carcinoma	GDSC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R565Q	BICR10	upper_aerodigestive_tract	COSMIC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R557W	TCGA-CG-5723	STAD	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R557W	DO38376	STAD	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R565W	TCGA-CV-5977	HNSC	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R565W	DO14403	HNSC	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R565W	DO50879	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P578L	TCGA-EB-A3HV	SKCM	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P578L	DO37647	SKCM	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R557L	TCGA-FS-A1ZG	SKCM	TCGA	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R557L	DO37523	SKCM	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A568V	DO228916	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.5825
p.V573F	DO229031	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E558D	DO229036	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R556L	DO229037	LICA	ICGC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R557Q	SIDM02013	Colorectal Carcinoma	GDSC	RNALFPE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVT2	Mitotic interactor and substrate of PLK1	LIG_APCC_ABBAyCdc20_2	566:572	RNALFPE	APC,CDC20,FZR1	0.9733	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons