DegronMD

Uniprot ID: Q14451

Source protein: Growth factor receptor-bound protein 7

Source gene: GRB7

Class: DEG_SCF_FBW7_1

Location: 21:27

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 79.9714

COIL: 0.9644

CONS_SCORE: 0.446

DSS_SCORE: 0.8671

HELIX: 0.0084

FCONS_SCORE: 1.0434

RIG_SCORE: 0.4477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A23T	TCGA-A5-A0G2	UCEC	TCGA	PGTPPGT	DEG_SCF_FBW7_1	0.7139
p.A23T	DO41235	UCEC	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.7139
p.S14F	TCGA-D3-A8GM	SKCM	TCGA	PGTPPGT	DEG_SCF_FBW7_1	0.1389
p.S14F	DO50288	SKCM	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.1389
p.S14F	SIDM01059	Melanoma	GDSC	PGTPPGT	DEG_SCF_FBW7_1	0.1389
p.S14F	IPC-298	skin	COSMIC	PGTPPGT	DEG_SCF_FBW7_1	0.1389
p.D22H	TCGA-EY-A3QX	UCEC	TCGA	PGTPPGT	DEG_SCF_FBW7_1	0.7688
p.D22H	DO48176	UCEC	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.7688
p.A23V	TCGA-FI-A2D5	UCEC	TCGA	PGTPPGT	DEG_SCF_FBW7_1	0.6936
p.A23V	DO41331	UCEC	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.6936
p.C20R	DO229010	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.3056
p.C20R	DO229013	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.3056
p.C20R	DO229016	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.3056
p.C20R	DO229003	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.3056
p.C20R	DO229005	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.3056
p.S12G	DO20873	KIRP	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.0833
p.M24V	DO45049	LINC	ICGC	PGTPPGT	DEG_SCF_FBW7_1	0.7208
p.T12P	SIDM00950	Pancreatic Carcinoma	GDSC	PGTPPGT	DEG_SCF_FBW7_1	0.0833
p.D27N	SIDM00562	Breast Carcinoma	GDSC	PGTPPGT	DEG_SCF_FBW7_1	0.6932
p.D27N	MRK-nu-1	breast	COSMIC	PGTPPGT	DEG_SCF_FBW7_1	0.6932
p.P21L	ACH-000238	Head and Neck Cancer	CCLE	PGTPPGT	DEG_SCF_FBW7_1	0.6471
p.P21L	SCC-4	upper_aerodigestive_tract	COSMIC	PGTPPGT	DEG_SCF_FBW7_1	0.6471
p.R29Q	CAL-54	kidney	COSMIC	PGTPPGT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14451	Growth factor receptor-bound protein 7	DEG_SCF_FBW7_1	21:27	PGTPPGT	FBXW7	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons