DegronMD - Q14451(GRB7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P105S	TCGA-55-7994	LUAD	TCGA	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.6752
p.P105S	DO45311	LUAD	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.6752
p.P118T	TCGA-90-A4ED	LUSC	TCGA	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.0833
p.P118T	DO45482	LUSC	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.0833
p.P118L	TCGA-90-A4ED	LUSC	TCGA	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.0833
p.P118L	DO45482	LUSC	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.0833
p.A23T	TCGA-A5-A0G2	UCEC	TCGA	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.7139
p.A23T	DO41235	UCEC	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.7139
p.S34I	TCGA-AX-A06F	UCEC	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation altering degron motif	0.7341
p.S34I	DO41752	UCEC	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation altering degron motif	0.7341
p.S14F	TCGA-D3-A8GM	SKCM	TCGA	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.1389
p.S14F	DO50288	SKCM	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.1389
p.S14F	SIDM01059	Melanoma	GDSC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.1389
p.S14F	IPC-298	skin	COSMIC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.1389
p.D39N	TCGA-DA-A960	SKCM	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.2778
p.D39N	DO219482	SKCM	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.2778
p.L117F	TCGA-EE-A2M5	SKCM	TCGA	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1111
p.L117F	DO37425	SKCM	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1111
p.S99R	TCGA-EJ-5511	PRAD	TCGA	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1944
p.S99R	DO36324	PRAD	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1944
p.L33F	TCGA-ER-A42L	SKCM	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation altering degron motif	0.6981
p.L33F	DO223910	SKCM	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation altering degron motif	0.6981
p.D22H	TCGA-EY-A3QX	UCEC	TCGA	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.7688
p.D22H	DO48176	UCEC	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.7688
p.P31L	TCGA-F4-6570	COAD	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation altering degron motif	0.6471
p.P31L	DO10443	COAD	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation altering degron motif	0.6471
p.A23V	TCGA-FI-A2D5	UCEC	TCGA	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.6936
p.A23V	DO41331	UCEC	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.6936
p.E96K	TCGA-FW-A3R5	SKCM	TCGA	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1111
p.E96K	DO37406	SKCM	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1111
p.S35G	TCGA-G7-7502	KIRP	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation altering degron motif	0.6993
p.I106N	TCGA-L5-A8NS	ESCA	TCGA	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.728
p.I106N	DO46973	RECA	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.728
p.S112R	TCGA-L5-A8NS	ESCA	TCGA	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.25
p.K40N	DO6144	BRCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation substituting flanking lysine	0.3611
p.C20R	DO229010	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.3056
p.C20R	DO229010	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.0556
p.C20R	DO229013	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.3056
p.C20R	DO229013	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.0556
p.C20R	DO229016	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.3056
p.C20R	DO229016	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.0556
p.C20R	DO229003	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.3056
p.C20R	DO229003	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.0556
p.C20R	DO229005	COCA	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.3056
p.C20R	DO229005	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.0556
p.S12G	DO20873	KIRP	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.0833
p.S99C	DO228194	LICA	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1944
p.M24V	DO45049	LINC	ICGC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.7208
p.G108E	DO220851	MELA	ICGC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.7199
p.G115E	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1667
p.G115E	SU-DHL-8	NS	COSMIC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.1667
p.T12P	SIDM00950	Pancreatic Carcinoma	GDSC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.0833
p.G108R	SIDM00142	Endometrial Carcinoma	GDSC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.7568
p.G108R	SIDM01187	Breast Carcinoma	GDSC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.7568
p.G108R	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.7568
p.D27N	SIDM00562	Breast Carcinoma	GDSC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.6932
p.D27N	MRK-nu-1	breast	COSMIC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.6932
p.P44L	SIDM01081	Oral Cavity Carcinoma	GDSC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.1389
p.P44L	SCC-4	upper aerodigestive tract	COSMIC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.1389
p.P100H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.2222
p.P100H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation rewiring degron network	0.2222
p.P21L	ACH-000238	Head and Neck Cancer	CCLE	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.6471
p.P21L	SCC-4	upper aerodigestive tract	COSMIC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation altering degron motif	0.6471
p.E109D	ACH-000579	Skin Cancer	CCLE	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.5647
p.E109D	UACC-257	skin	COSMIC	VKVYSE	LIG_APCC_ABBA_1	104:109	Mutation altering degron motif	0.5647
p.R29Q	CAL-54	kidney	COSMIC	PGTPPGT	DEG_SCF_FBW7_1	21:27	Mutation rewiring degron network	0.2778
p.R29Q	CAL-54	kidney	COSMIC	PPDTPLPE	DEG_SCF_FBW7_2	30:37	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRB7

UniProt ID: Q14451

Entrez ID: 2886

Protein name: Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for GRB7 in