DegronMD

Uniprot ID: Q14451

Source protein: Growth factor receptor-bound protein 7

Source gene: GRB7

Class: DEG_SCF_FBW7_2

Location: 30:37

E3 ligase: FBXW7

DEGRON score: 0.5841

ASA_SCORE: 95.225

COIL: 0.8985

CONS_SCORE: 0.3931

DSS_SCORE: 0.8325

HELIX: 0.0901

FCONS_SCORE: 0.8941

RIG_SCORE: 0.5869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S34I	TCGA-AX-A06F	UCEC	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	0.7341
p.S34I	DO41752	UCEC	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.7341
p.D39N	TCGA-DA-A960	SKCM	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	0.2778
p.D39N	DO219482	SKCM	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.2778
p.L33F	TCGA-ER-A42L	SKCM	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	0.6981
p.L33F	DO223910	SKCM	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.6981
p.P31L	TCGA-F4-6570	COAD	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	0.6471
p.P31L	DO10443	COAD	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.6471
p.S35G	TCGA-G7-7502	KIRP	TCGA	PPDTPLPE	DEG_SCF_FBW7_2	0.6993
p.K40N	DO6144	BRCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.3611
p.C20R	DO229010	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.0556
p.C20R	DO229013	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.0556
p.C20R	DO229016	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.0556
p.C20R	DO229003	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.0556
p.C20R	DO229005	COCA	ICGC	PPDTPLPE	DEG_SCF_FBW7_2	0.0556
p.P44L	SIDM01081	Oral Cavity Carcinoma	GDSC	PPDTPLPE	DEG_SCF_FBW7_2	0.1389
p.P44L	SCC-4	upper_aerodigestive_tract	COSMIC	PPDTPLPE	DEG_SCF_FBW7_2	0.1389
p.R29Q	CAL-54	kidney	COSMIC	PPDTPLPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14451	Growth factor receptor-bound protein 7	DEG_SCF_FBW7_2	30:37	PPDTPLPE	FBXW7	0.5841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons