DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VKVYSE
Uniprot ID:
Q14451
Source protein:
Growth factor receptor-bound protein 7
Source gene:
GRB7
Class:
LIG_APCC_ABBA_1
Location:
104:109
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6488
ASA_SCORE:
35.2167
COIL:
0.2068
CONS_SCORE:
0.4431
DSS_SCORE:
0.3519
HELIX:
0.0033
FCONS_SCORE:
1.0991
RIG_SCORE:
0.7857
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G108R
SIDM00142
Endometrial Carcinoma
GDSC
VKVYSE
LIG_APCC_ABBA_1
0.7568
p.G108R
SIDM01187
Breast Carcinoma
GDSC
VKVYSE
LIG_APCC_ABBA_1
0.7568
p.G108R
SIDM01086
B-Lymphoblastic Leukemia
GDSC
VKVYSE
LIG_APCC_ABBA_1
0.7568
p.I106N
TCGA-L5-A8NS
ESCA
TCGA
VKVYSE
LIG_APCC_ABBA_1
0.728
p.I106N
DO46973
RECA
ICGC
VKVYSE
LIG_APCC_ABBA_1
0.728
p.G108E
DO220851
MELA
ICGC
VKVYSE
LIG_APCC_ABBA_1
0.7199
p.P105S
TCGA-55-7994
LUAD
TCGA
VKVYSE
LIG_APCC_ABBA_1
0.6752
p.P105S
DO45311
LUAD
ICGC
VKVYSE
LIG_APCC_ABBA_1
0.6752
p.E109D
ACH-000579
Skin Cancer
CCLE
VKVYSE
LIG_APCC_ABBA_1
0.5647
p.E109D
UACC-257
skin
COSMIC
VKVYSE
LIG_APCC_ABBA_1
0.5647
p.S112R
TCGA-L5-A8NS
ESCA
TCGA
VKVYSE
LIG_APCC_ABBA_1
0.25
p.P100H
SIDM00429
B-Lymphoblastic Leukemia
GDSC
VKVYSE
LIG_APCC_ABBA_1
0.2222
p.P100H
NALM-6
haematopoietic_and_lymphoid_tissue
COSMIC
VKVYSE
LIG_APCC_ABBA_1
0.2222
p.S99R
TCGA-EJ-5511
PRAD
TCGA
VKVYSE
LIG_APCC_ABBA_1
0.1944
p.S99R
DO36324
PRAD
ICGC
VKVYSE
LIG_APCC_ABBA_1
0.1944
p.S99C
DO228194
LICA
ICGC
VKVYSE
LIG_APCC_ABBA_1
0.1944
p.G115E
SIDM00423
B-Cell Non-Hodgkin's Lymphoma
GDSC
VKVYSE
LIG_APCC_ABBA_1
0.1667
p.G115E
SU-DHL-8
NS
COSMIC
VKVYSE
LIG_APCC_ABBA_1
0.1667
p.L117F
TCGA-EE-A2M5
SKCM
TCGA
VKVYSE
LIG_APCC_ABBA_1
0.1111
p.L117F
DO37425
SKCM
ICGC
VKVYSE
LIG_APCC_ABBA_1
0.1111
p.E96K
TCGA-FW-A3R5
SKCM
TCGA
VKVYSE
LIG_APCC_ABBA_1
0.1111
p.E96K
DO37406
SKCM
ICGC
VKVYSE
LIG_APCC_ABBA_1
0.1111
p.P118T
TCGA-90-A4ED
LUSC
TCGA
VKVYSE
LIG_APCC_ABBA_1
0.0833
p.P118T
DO45482
LUSC
ICGC
VKVYSE
LIG_APCC_ABBA_1
0.0833
p.P118L
TCGA-90-A4ED
LUSC
TCGA
VKVYSE
LIG_APCC_ABBA_1
0.0833
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Drug responses associated with GRB7 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of VKVYSE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14451
Growth factor receptor-bound protein 7
LIG_APCC_ABBA_1
104:109
VKVYSE
APC,CDC20,FZR1
0.6488
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