DegronMD

Uniprot ID: Q14451

Source protein: Growth factor receptor-bound protein 7

Source gene: GRB7

Class: LIG_APCC_ABBA_1

Location: 104:109

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6488

ASA_SCORE: 35.2167

COIL: 0.2068

CONS_SCORE: 0.4431

DSS_SCORE: 0.3519

HELIX: 0.0033

FCONS_SCORE: 1.0991

RIG_SCORE: 0.7857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P105S	TCGA-55-7994	LUAD	TCGA	VKVYSE	LIG_APCC_ABBA_1	0.6752
p.P105S	DO45311	LUAD	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.6752
p.P118T	TCGA-90-A4ED	LUSC	TCGA	VKVYSE	LIG_APCC_ABBA_1	0.0833
p.P118T	DO45482	LUSC	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.0833
p.P118L	TCGA-90-A4ED	LUSC	TCGA	VKVYSE	LIG_APCC_ABBA_1	0.0833
p.P118L	DO45482	LUSC	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.0833
p.L117F	TCGA-EE-A2M5	SKCM	TCGA	VKVYSE	LIG_APCC_ABBA_1	0.1111
p.L117F	DO37425	SKCM	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.1111
p.S99R	TCGA-EJ-5511	PRAD	TCGA	VKVYSE	LIG_APCC_ABBA_1	0.1944
p.S99R	DO36324	PRAD	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.1944
p.E96K	TCGA-FW-A3R5	SKCM	TCGA	VKVYSE	LIG_APCC_ABBA_1	0.1111
p.E96K	DO37406	SKCM	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.1111
p.I106N	TCGA-L5-A8NS	ESCA	TCGA	VKVYSE	LIG_APCC_ABBA_1	0.728
p.I106N	DO46973	RECA	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.728
p.S112R	TCGA-L5-A8NS	ESCA	TCGA	VKVYSE	LIG_APCC_ABBA_1	0.25
p.S99C	DO228194	LICA	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.1944
p.G108E	DO220851	MELA	ICGC	VKVYSE	LIG_APCC_ABBA_1	0.7199
p.G115E	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKVYSE	LIG_APCC_ABBA_1	0.1667
p.G115E	SU-DHL-8	NS	COSMIC	VKVYSE	LIG_APCC_ABBA_1	0.1667
p.G108R	SIDM00142	Endometrial Carcinoma	GDSC	VKVYSE	LIG_APCC_ABBA_1	0.7568
p.G108R	SIDM01187	Breast Carcinoma	GDSC	VKVYSE	LIG_APCC_ABBA_1	0.7568
p.G108R	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VKVYSE	LIG_APCC_ABBA_1	0.7568
p.P100H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VKVYSE	LIG_APCC_ABBA_1	0.2222
p.P100H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYSE	LIG_APCC_ABBA_1	0.2222
p.E109D	ACH-000579	Skin Cancer	CCLE	VKVYSE	LIG_APCC_ABBA_1	0.5647
p.E109D	UACC-257	skin	COSMIC	VKVYSE	LIG_APCC_ABBA_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14451	Growth factor receptor-bound protein 7	LIG_APCC_ABBA_1	104:109	VKVYSE	APC,CDC20,FZR1	0.6488	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKVYSE

Degron related mutations and impact score

Drug responses associated with GRB7 mutations

All proteins holding degron of VKVYSE