DegronMD

Uniprot ID: Q99728

Source protein: BRCA1-associated RING domain protein 1

Source gene: BARD1

Class: DEG_SCF_FBW7_1

Location: 392:398

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 78.0857

COIL: 0.9247

CONS_SCORE: 0.4074

DSS_SCORE: 0.5545

HELIX: 0.0546

FCONS_SCORE: 1.1717

RIG_SCORE: 0.5721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R406Q	TCGA-AP-A0LM	UCEC	TCGA	PGTPPST	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO43306	UCEC	ICGC	PGTPPST	DEG_SCF_FBW7_1	0.1111
p.G393S	TCGA-AX-A2HD	UCEC	TCGA	PGTPPST	DEG_SCF_FBW7_1	0.5882
p.G393S	DO42608	UCEC	ICGC	PGTPPST	DEG_SCF_FBW7_1	0.5882
p.I388V	TCGA-CV-7437	HNSC	TCGA	PGTPPST	DEG_SCF_FBW7_1	0.2222
p.I388V	DO14902	HNSC	ICGC	PGTPPST	DEG_SCF_FBW7_1	0.2222
p.T394A	TCGA-FB-AAQ6	PAAD	TCGA	PGTPPST	DEG_SCF_FBW7_1	0.825
p.T394A	DO218971	PAAD	ICGC	PGTPPST	DEG_SCF_FBW7_1	0.825
p.V407M	DO222946	BTCA	ICGC	PGTPPST	DEG_SCF_FBW7_1	0.0833
p.S397F	DO233169	GACA	ICGC	PGTPPST	DEG_SCF_FBW7_1	0.6871
p.R405M	SIDM00241	Breast Carcinoma	GDSC	PGTPPST	DEG_SCF_FBW7_1	0.1389
p.R405M	ACH-002179	Breast Cancer	CCLE	PGTPPST	DEG_SCF_FBW7_1	0.1389
p.R405M	OCUB-M	breast	COSMIC	PGTPPST	DEG_SCF_FBW7_1	0.1389
p.R386M	OCUB-M	breast	COSMIC	PGTPPST	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99728	BRCA1-associated RING domain protein 1	DEG_SCF_FBW7_1	392:398	PGTPPST	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons