DegronMD - Q99728(BARD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K140N	TCGA-AG-3892	READ	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation substituting flanking lysine	0.3056
p.K140N	TCGA-AP-A056	UCEC	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation substituting flanking lysine	0.3056
p.K140N	TCGA-BK-A6W3	UCEC	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation substituting flanking lysine	0.3056
p.K140N	DO36394	READ	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation substituting flanking lysine	0.3056
p.K140N	DO50076	UCEC	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation substituting flanking lysine	0.3056
p.K140N	DO43971	UCEC	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation substituting flanking lysine	0.3056
p.R406Q	TCGA-AP-A0LM	UCEC	TCGA	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.1111
p.R406Q	DO43306	UCEC	ICGC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.1111
p.G393S	TCGA-AX-A2HD	UCEC	TCGA	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation altering degron motif	0.5882
p.G393S	DO42608	UCEC	ICGC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation altering degron motif	0.5882
p.N141T	TCGA-CA-6717	COAD	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.1667
p.N141T	DO8264	COAD	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.1667
p.I388V	TCGA-CV-7437	HNSC	TCGA	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.2222
p.I388V	DO14902	HNSC	ICGC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.2222
p.K124T	TCGA-DU-6392	LGG	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation blocking ubiquitination signal	0.6389
p.K124T	DO22237	LGG	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation blocking ubiquitination signal	0.6389
p.T394A	TCGA-FB-AAQ6	PAAD	TCGA	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation altering degron motif	0.825
p.T394A	DO218971	PAAD	ICGC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation altering degron motif	0.825
p.V407M	DO222946	BTCA	ICGC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.0833
p.V134F	DO223732	CESC	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation altering degron motif	0.7068
p.S397F	DO233169	GACA	ICGC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation altering degron motif	0.6871
p.E124K	DO50970	LICA	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation blocking ubiquitination signal	0.6389
p.E124K	DO232761	PBCA	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation blocking ubiquitination signal	0.6389
p.P137S	DO46801	PRAD	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.2778
p.S121P	SIDM00193	Colorectal Carcinoma	GDSC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.1111
p.S121P	ACH-000991	Colon/Colorectal Cancer	CCLE	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.1111
p.S121P	SNU-81	large intestine	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.1111
p.R405M	SIDM00241	Breast Carcinoma	GDSC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.1389
p.R405M	ACH-002179	Breast Cancer	CCLE	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.1389
p.R405M	OCUB-M	breast	COSMIC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.1389
p.V135F	TGBC1TKB	biliary tract	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation altering degron motif	0.7068
p.V144L	NCI-H1648	lung	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation substituting flanking lysine	0.1944
p.R386M	OCUB-M	breast	COSMIC	PGTPPST	DEG_SCF_FBW7_1	392:398	Mutation rewiring degron network	0.1667
p.G122A	NCI-H510A	lung	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.1389
p.R123Q	HCC-56	large intestine	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.1667
p.T128N	EJM	haematopoietic and lymphoid tissue	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	129:135	Mutation rewiring degron network	0.3056

Kaplan plot for BARD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BARD1

UniProt ID: Q99728

Entrez ID: 580

Protein name: BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BARD1 in