DegronMD

Uniprot ID: Q99728

Source protein: BRCA1-associated RING domain protein 1

Source gene: BARD1

Class: LIG_APCC_ABBAyCdc20_2

Location: 129:135

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7491

ASA_SCORE: 101.1571

COIL: 0.7647

CONS_SCORE: 0.3178

DSS_SCORE: 0.5029

HELIX: 0.1867

FCONS_SCORE: 0.9681

RIG_SCORE: 0.731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K140N	TCGA-AG-3892	READ	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.3056
p.K140N	TCGA-AP-A056	UCEC	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.3056
p.K140N	TCGA-BK-A6W3	UCEC	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.3056
p.K140N	DO36394	READ	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.3056
p.K140N	DO50076	UCEC	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.3056
p.K140N	DO43971	UCEC	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.3056
p.N141T	TCGA-CA-6717	COAD	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.1667
p.N141T	DO8264	COAD	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.1667
p.K124T	TCGA-DU-6392	LGG	TCGA	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.6389
p.K124T	DO22237	LGG	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.6389
p.V134F	DO223732	CESC	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.7068
p.E124K	DO50970	LICA	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.6389
p.E124K	DO232761	PBCA	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.6389
p.P137S	DO46801	PRAD	ICGC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.2778
p.S121P	SIDM00193	Colorectal Carcinoma	GDSC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.1111
p.S121P	ACH-000991	Colon/Colorectal Cancer	CCLE	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.1111
p.S121P	SNU-81	large_intestine	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.1111
p.V135F	TGBC1TKB	biliary_tract	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.7068
p.V144L	NCI-H1648	lung	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.1944
p.G122A	NCI-H510A	lung	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.1389
p.R123Q	HCC-56	large_intestine	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.1667
p.T128N	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	RKSLFND	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99728	BRCA1-associated RING domain protein 1	LIG_APCC_ABBAyCdc20_2	129:135	RKSLFND	APC,CDC20,FZR1	0.7491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons