DegronMD

Uniprot ID: Q9UDY2

Source protein: Tight junction protein ZO-2

Source gene: TJP2

Class: DEG_SCF_FBW7_1

Location: 1129:1135

E3 ligase: FBXW7

DEGRON score: 0.9605

ASA_SCORE: 84.7429

COIL: 0.9473

CONS_SCORE: 0.4032

DSS_SCORE: 0.8997

HELIX: 0.0244

FCONS_SCORE: 0.888

RIG_SCORE: 0.5018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1140K	TCGA-AG-A002	READ	TCGA	PGTPQHT	DEG_SCF_FBW7_1	0.1944
p.E1140K	TCGA-FU-A3HZ	CESC	TCGA	PGTPQHT	DEG_SCF_FBW7_1	0.1944
p.E1140K	DO6308	CESC	ICGC	PGTPQHT	DEG_SCF_FBW7_1	0.1944
p.E1140K	SNU-81	large_intestine	COSMIC	PGTPQHT	DEG_SCF_FBW7_1	0.1944
p.M1128I	TCGA-AJ-A3BG	UCEC	TCGA	PGTPQHT	DEG_SCF_FBW7_1	0.3056
p.M1128I	DO42633	UCEC	ICGC	PGTPQHT	DEG_SCF_FBW7_1	0.3056
p.E1140D	TCGA-EO-A3AY	UCEC	TCGA	PGTPQHT	DEG_SCF_FBW7_1	0.1944
p.E1140D	DO43202	UCEC	ICGC	PGTPQHT	DEG_SCF_FBW7_1	0.1944
p.R1138S	TCGA-HU-8602	STAD	TCGA	PGTPQHT	DEG_SCF_FBW7_1	0.25
p.R1138S	DO47829	STAD	ICGC	PGTPQHT	DEG_SCF_FBW7_1	0.25
p.Q1129H	TCGA-NC-A5HQ	LUSC	TCGA	PGTPQHT	DEG_SCF_FBW7_1	0.7582
p.Q1129H	DO219201	LUSC	ICGC	PGTPQHT	DEG_SCF_FBW7_1	0.7582
p.M1119I	DO231982	LICA	ICGC	PGTPQHT	DEG_SCF_FBW7_1	0.0556
p.M1119V	DO32972	PACA	ICGC	PGTPQHT	DEG_SCF_FBW7_1	0.0556
p.L1125I	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTPQHT	DEG_SCF_FBW7_1	0.2222
p.L1125I	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPQHT	DEG_SCF_FBW7_1	0.2222
p.I1139M	SIDM00983	Bladder Carcinoma	GDSC	PGTPQHT	DEG_SCF_FBW7_1	0.2222
p.I1139M	647-V	urinary_tract	COSMIC	PGTPQHT	DEG_SCF_FBW7_1	0.2222
p.I1122N	ACH-000946	Endometrial/Uterine Cancer	CCLE	PGTPQHT	DEG_SCF_FBW7_1	0.1389
p.Y1133H	JHH-2	liver	COSMIC	PGTPQHT	DEG_SCF_FBW7_1	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UDY2	Tight junction protein ZO-2	DEG_SCF_FBW7_1	1129:1135	PGTPQHT	FBXW7	0.9605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons