DegronMD - Q9UDY2(TJP2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D456H	TCGA-4Z-AA7M	BLCA	TCGA	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation altering degron motif	0.7688
p.D456H	DO218976	BLCA	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation altering degron motif	0.7688
p.R451C	TCGA-A6-6780	COAD	TCGA	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.1944
p.R451C	TCGA-AX-A06F	UCEC	TCGA	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.1944
p.R451C	DO10244	COAD	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.1944
p.R451C	DO41752	UCEC	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.1944
p.E1140K	TCGA-AG-A002	READ	TCGA	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.1944
p.E1140K	TCGA-FU-A3HZ	CESC	TCGA	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.1944
p.E1140K	DO6308	CESC	ICGC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.1944
p.E1140K	SNU-81	large intestine	COSMIC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.1944
p.M1128I	TCGA-AJ-A3BG	UCEC	TCGA	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.3056
p.M1128I	DO42633	UCEC	ICGC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.3056
p.P470S	TCGA-AX-A0J1	UCEC	TCGA	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.0833
p.P470S	DO41199	UCEC	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.0833
p.K467N	TCGA-D3-A2JP	SKCM	TCGA	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.1667
p.K467N	DO47407	SKCM	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.1667
p.E1140D	TCGA-EO-A3AY	UCEC	TCGA	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.1944
p.E1140D	DO43202	UCEC	ICGC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.1944
p.P447T	TCGA-FS-A1ZN	SKCM	TCGA	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.0833
p.P447T	DO38165	SKCM	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.0833
p.P447S	TCGA-GN-A266	SKCM	TCGA	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.0833
p.P447S	DO37432	SKCM	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.0833
p.R1138S	TCGA-HU-8602	STAD	TCGA	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.25
p.R1138S	DO47829	STAD	ICGC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.25
p.Q1129H	TCGA-NC-A5HQ	LUSC	TCGA	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation altering degron motif	0.7582
p.Q1129H	DO219201	LUSC	ICGC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation altering degron motif	0.7582
p.R451H	DO233634	GACA	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.1944
p.M1119I	DO231982	LICA	ICGC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.0556
p.M1119V	DO32972	PACA	ICGC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.0556
p.E449K	DO46977	RECA	ICGC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation rewiring degron network	0.1389
p.L1125I	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.2222
p.L1125I	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.2222
p.D458N	SIDM00889	Cervical Carcinoma	GDSC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation altering degron motif	0.6932
p.D458N	C-33-A	cervix	COSMIC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation altering degron motif	0.6932
p.I1139M	SIDM00983	Bladder Carcinoma	GDSC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.2222
p.I1139M	647-V	urinary tract	COSMIC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.2222
p.I1122N	ACH-000946	Endometrial/Uterine Cancer	CCLE	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation rewiring degron network	0.1389
p.E462D	HT-115	large intestine	COSMIC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation blocking phosphorylation signal	0.75
p.E458A	HT55	large intestine	COSMIC	PTPFKS	DEG_SCF_FBW7_1	456:461	Mutation altering degron motif	0.7701
p.Y1133H	JHH-2	liver	COSMIC	PGTPQHT	DEG_SCF_FBW7_1	1129:1135	Mutation altering degron motif	0.7229

Kaplan plot for TJP2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TJP2

UniProt ID: Q9UDY2

Entrez ID: 9414

Protein name: Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TJP2 in