DegronMD

Uniprot ID: Q9UDY2

Source protein: Tight junction protein ZO-2

Source gene: TJP2

Class: DEG_SCF_FBW7_1

Location: 456:461

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 86.3833

COIL: 0.9262

CONS_SCORE: 0.344

DSS_SCORE: 0.6815

HELIX: 0.019

FCONS_SCORE: 1.0108

RIG_SCORE: 0.6238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D456H	TCGA-4Z-AA7M	BLCA	TCGA	PTPFKS	DEG_SCF_FBW7_1	0.7688
p.D456H	DO218976	BLCA	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.7688
p.R451C	TCGA-A6-6780	COAD	TCGA	PTPFKS	DEG_SCF_FBW7_1	0.1944
p.R451C	TCGA-AX-A06F	UCEC	TCGA	PTPFKS	DEG_SCF_FBW7_1	0.1944
p.R451C	DO10244	COAD	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.1944
p.R451C	DO41752	UCEC	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.1944
p.P470S	TCGA-AX-A0J1	UCEC	TCGA	PTPFKS	DEG_SCF_FBW7_1	0.0833
p.P470S	DO41199	UCEC	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.0833
p.K467N	TCGA-D3-A2JP	SKCM	TCGA	PTPFKS	DEG_SCF_FBW7_1	0.1667
p.K467N	DO47407	SKCM	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.1667
p.P447T	TCGA-FS-A1ZN	SKCM	TCGA	PTPFKS	DEG_SCF_FBW7_1	0.0833
p.P447T	DO38165	SKCM	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.0833
p.P447S	TCGA-GN-A266	SKCM	TCGA	PTPFKS	DEG_SCF_FBW7_1	0.0833
p.P447S	DO37432	SKCM	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.0833
p.R451H	DO233634	GACA	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.1944
p.E449K	DO46977	RECA	ICGC	PTPFKS	DEG_SCF_FBW7_1	0.1389
p.D458N	SIDM00889	Cervical Carcinoma	GDSC	PTPFKS	DEG_SCF_FBW7_1	0.6932
p.D458N	C-33-A	cervix	COSMIC	PTPFKS	DEG_SCF_FBW7_1	0.6932
p.E462D	HT-115	large_intestine	COSMIC	PTPFKS	DEG_SCF_FBW7_1	0.75
p.E458A	HT55	large_intestine	COSMIC	PTPFKS	DEG_SCF_FBW7_1	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UDY2	Tight junction protein ZO-2	DEG_SCF_FBW7_1	456:461	PTPFKS	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons