DegronMD

Uniprot ID: P35269

Source protein: General transcription factor IIF subunit 1

Source gene: GTF2F1

Class: DEG_SCF_FBW7_2

Location: 387:393

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 89.8714

COIL: 0.956

CONS_SCORE: 0.495

DSS_SCORE: 0.7966

HELIX: 0.0249

FCONS_SCORE: 1.1472

RIG_SCORE: 0.4802

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A392T	TCGA-EO-A22X	UCEC	TCGA	PGTPSAE	DEG_SCF_FBW7_2	0.6028
p.S381P	TCGA-EY-A215	UCEC	TCGA	PGTPSAE	DEG_SCF_FBW7_2	0.6111
p.P390S	TCGA-G4-6309	COAD	TCGA	PGTPSAE	DEG_SCF_FBW7_2	0.6752
p.S377L	TCGA-MT-A67G	HNSC	TCGA	PGTPSAE	DEG_SCF_FBW7_2	0.5
p.K391T	DO23562	LUAD	ICGC	PGTPSAE	DEG_SCF_FBW7_2	0.7306
p.L378V	DO29046	OV	ICGC	PGTPSAE	DEG_SCF_FBW7_2	0.0833
p.A403V	SIDM00545	Melanoma	GDSC	PGTPSAE	DEG_SCF_FBW7_2	0.0556
p.G383D	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PGTPSAE	DEG_SCF_FBW7_2	0.2222
p.G383D	ACH-000563	Lung Cancer	CCLE	PGTPSAE	DEG_SCF_FBW7_2	0.2222
p.R386S	SIDM00901	Endometrial Carcinoma	GDSC	PGTPSAE	DEG_SCF_FBW7_2	0.3056
p.R386S	ACH-000940	Endometrial/Uterine Cancer	CCLE	PGTPSAE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35269	General transcription factor IIF subunit 1	DEG_SCF_FBW7_2	387:393	PGTPSAE	FBXW7	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons