DegronMD

Uniprot ID: Q4KMP7

Source protein: TBC1 domain family member 10B

Source gene: TBC1D10B

Class: DEG_SCF_FBW7_1

Location: 146:152

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 78.1143

COIL: 0.9463

CONS_SCORE: 0.3834

DSS_SCORE: 0.8833

HELIX: 0.012

FCONS_SCORE: 0.9884

RIG_SCORE: 0.4537

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T152N	DO228974	LICA	ICGC	PGTPTGT	DEG_SCF_FBW7_1	0.8166
p.G145R	DO229446	SKCA	ICGC	PGTPTGT	DEG_SCF_FBW7_1	0.3056
p.P146S	DO229479	SKCA	ICGC	PGTPTGT	DEG_SCF_FBW7_1	0.6752
p.P146L	DO229479	SKCA	ICGC	PGTPTGT	DEG_SCF_FBW7_1	0.6471
p.P149T	SIDM00039	Ovarian Carcinoma	GDSC	PGTPTGT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KMP7	TBC1 domain family member 10B	DEG_SCF_FBW7_1	146:152	PGTPTGT	FBXW7	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons