DegronMD - Q4KMP7(TBC1D10B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A167T	TCGA-B8-A54J	KIRC	TCGA	PTRTPSRT	DEG_SCF_FBW7_1	153:160	Mutation rewiring degron network	0.1389
p.A167T	DO44458	KIRC	ICGC	PTRTPSRT	DEG_SCF_FBW7_1	153:160	Mutation rewiring degron network	0.1389
p.N242K	DO222884	COCA	ICGC	VTVTPAPE	DEG_SCF_FBW7_2	231:238	Mutation rewiring degron network	0.2222
p.T152N	DO228974	LICA	ICGC	PGTPTGT	DEG_SCF_FBW7_1	146:152	Mutation altering degron motif	0.8166
p.A229V	DO228851	MALY	ICGC	VTVTPAPE	DEG_SCF_FBW7_2	231:238	Mutation rewiring degron network	0.2778
p.P235S	DO222595	MELA	ICGC	VTVTPAPE	DEG_SCF_FBW7_2	231:238	Mutation altering degron motif	0.6752
p.G145R	DO229446	SKCA	ICGC	PGTPTGT	DEG_SCF_FBW7_1	146:152	Mutation rewiring degron network	0.3056
p.G145R	DO229446	SKCA	ICGC	PTRTPSRT	DEG_SCF_FBW7_1	153:160	Mutation rewiring degron network	0.1111
p.P146S	DO229479	SKCA	ICGC	PGTPTGT	DEG_SCF_FBW7_1	146:152	Mutation altering degron motif	0.6752
p.P146L	DO229479	SKCA	ICGC	PGTPTGT	DEG_SCF_FBW7_1	146:152	Mutation altering degron motif	0.6471
p.T166I	DO42673	UCEC	ICGC	PTRTPSRT	DEG_SCF_FBW7_1	153:160	Mutation rewiring degron network	0.1667
p.P149T	SIDM00039	Ovarian Carcinoma	GDSC	PGTPTGT	DEG_SCF_FBW7_1	146:152	Mutation altering degron motif	0.7031

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons