DegronMD

Uniprot ID: Q4KMP7

Source protein: TBC1 domain family member 10B

Source gene: TBC1D10B

Class: DEG_SCF_FBW7_2

Location: 231:238

E3 ligase: FBXW7

DEGRON score: 0.926

ASA_SCORE: 90.55

COIL: 0.9565

CONS_SCORE: 0.3846

DSS_SCORE: 0.6343

HELIX: 0.0114

FCONS_SCORE: 0.982

RIG_SCORE: 0.7327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N242K	DO222884	COCA	ICGC	VTVTPAPE	DEG_SCF_FBW7_2	0.2222
p.A229V	DO228851	MALY	ICGC	VTVTPAPE	DEG_SCF_FBW7_2	0.2778
p.P235S	DO222595	MELA	ICGC	VTVTPAPE	DEG_SCF_FBW7_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KMP7	TBC1 domain family member 10B	DEG_SCF_FBW7_2	231:238	VTVTPAPE	FBXW7	0.926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons