DegronMD

Uniprot ID: Q4KMP7

Source protein: TBC1 domain family member 10B

Source gene: TBC1D10B

Class: DEG_SCF_FBW7_1

Location: 153:160

E3 ligase: FBXW7

DEGRON score: 0.9553

ASA_SCORE: 96.0125

COIL: 0.9281

CONS_SCORE: 0.3837

DSS_SCORE: 0.8383

HELIX: 0.0198

FCONS_SCORE: 0.9836

RIG_SCORE: 0.5955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A167T	TCGA-B8-A54J	KIRC	TCGA	PTRTPSRT	DEG_SCF_FBW7_1	0.1389
p.A167T	DO44458	KIRC	ICGC	PTRTPSRT	DEG_SCF_FBW7_1	0.1389
p.G145R	DO229446	SKCA	ICGC	PTRTPSRT	DEG_SCF_FBW7_1	0.1111
p.T166I	DO42673	UCEC	ICGC	PTRTPSRT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KMP7	TBC1 domain family member 10B	DEG_SCF_FBW7_1	153:160	PTRTPSRT	FBXW7	0.9553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons