DegronMD

Uniprot ID: Q9NQX5

Source protein: Neural proliferation differentiation and control protein 1

Source gene: NPDC1

Class: DEG_SCF_FBW7_1

Location: 148:154

E3 ligase: FBXW7

DEGRON score: 0.9186

ASA_SCORE: 84.8

COIL: 0.9613

CONS_SCORE: 0.3232

DSS_SCORE: 0.7858

HELIX: 0.012

FCONS_SCORE: 0.9862

RIG_SCORE: 0.5189

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G149R	TCGA-A5-A2K7	UCEC	TCGA	PGTPTPT	DEG_SCF_FBW7_1	0.6457
p.R161H	DO10880	GBM	ICGC	PGTPTPT	DEG_SCF_FBW7_1	0.1389
p.P158T	DO229041	LICA	ICGC	PGTPTPT	DEG_SCF_FBW7_1	0.2222
p.P147T	DO229063	LICA	ICGC	PGTPTPT	DEG_SCF_FBW7_1	0.3056
p.R161C	DO51407	PRAD	ICGC	PGTPTPT	DEG_SCF_FBW7_1	0.1389
p.G139E	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PGTPTPT	DEG_SCF_FBW7_1	0.0833
p.G139E	ACH-000636	Leukemia	CCLE	PGTPTPT	DEG_SCF_FBW7_1	0.0833
p.G139E	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPTPT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQX5	Neural proliferation differentiation and control protein 1	DEG_SCF_FBW7_1	148:154	PGTPTPT	FBXW7	0.9186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons