DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 4034:4038

E3 ligase: SPOP

DEGRON score: 0.5709

ASA_SCORE: 96.84

COIL: 0.8694

CONS_SCORE: 0.5735

DSS_SCORE: 0.638

HELIX: 0.0118

FCONS_SCORE: 0.9318

RIG_SCORE: 0.6256

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4030V	TCGA-AB-2826	LAML	TCGA	PHTST	DEG_SPOP_SBC_1	0.2222
p.A4030V	DO21833	LAML	ICGC	PHTST	DEG_SPOP_SBC_1	0.2222
p.T4033S	TCGA-FW-A3R5	SKCM	TCGA	PHTST	DEG_SPOP_SBC_1	0.3056
p.T4033S	DO37406	SKCM	ICGC	PHTST	DEG_SPOP_SBC_1	0.3056
p.T4033I	TCGA-FW-A3R5	SKCM	TCGA	PHTST	DEG_SPOP_SBC_1	0.3056
p.T4033I	DO37406	SKCM	ICGC	PHTST	DEG_SPOP_SBC_1	0.3056
p.R4043C	TCGA-IQ-7630	HNSC	TCGA	PHTST	DEG_SPOP_SBC_1	0.1944
p.R4043C	DO14654	HNSC	ICGC	PHTST	DEG_SPOP_SBC_1	0.1944
p.R4043C	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PHTST	DEG_SPOP_SBC_1	0.1944
p.R4043C	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PHTST	DEG_SPOP_SBC_1	0.1944
p.S4039F	DO225046	BRCA	ICGC	PHTST	DEG_SPOP_SBC_1	0.3056
p.R4043H	DO233935	GACA	ICGC	PHTST	DEG_SPOP_SBC_1	0.1944
p.S4032I	DO229028	LICA	ICGC	PHTST	DEG_SPOP_SBC_1	0.2778
p.T4027M	DO229022	LICA	ICGC	PHTST	DEG_SPOP_SBC_1	0.1389
p.A4030P	DO231204	LUSC	ICGC	PHTST	DEG_SPOP_SBC_1	0.2222
p.T4027A	SIDM00498	Colorectal Carcinoma	GDSC	PHTST	DEG_SPOP_SBC_1	0.1389
p.T4027A	ACH-000970	Colon/Colorectal Cancer	CCLE	PHTST	DEG_SPOP_SBC_1	0.1389
p.T4027A	SNU-C5	large_intestine	COSMIC	PHTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4034:4038	PHTST	SPOP	0.5709	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons