DegronMD

Uniprot ID: O60784

Source protein: Target of Myb protein 1

Source gene: TOM1

Class: DEG_SCF_FBW7_1

Location: 161:168

E3 ligase: FBXW7

DEGRON score: 0.9884

ASA_SCORE: 93.925

COIL: 0.908

CONS_SCORE: 0.4537

DSS_SCORE: 0.5566

HELIX: 0.0365

FCONS_SCORE: 0.9671

RIG_SCORE: 0.7323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V169M	TCGA-EK-A2RL	CESC	TCGA	PIHTPQRT	DEG_SCF_FBW7_1	0.3056
p.E169Q	DO51906	BLCA	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	0.3056
p.L171V	DO222736	BTCA	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	0.25
p.E158D	DO48582	KIRP	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	0.25
p.M159L	DO48582	KIRP	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	0.2778
p.S155R	DO42033	UCEC	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	0.1667
p.T172M	DO42985	UCEC	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	0.2222
p.R154C	DO41871	UCEC	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	0.5833
p.P161L	SIDM00806	Osteosarcoma	GDSC	PIHTPQRT	DEG_SCF_FBW7_1	0.6471
p.P161L	HOS	bone	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	0.6471
p.I158V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	0.25
p.A155T	LoVo	large_intestine	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	0.1667
p.I170V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	0.2778
p.A167T	LoVo	large_intestine	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	0.7139
p.L153V	HT-1376	urinary_tract	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	0.1111
p.L165V	HT-1376	urinary_tract	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	0.6765
p.D157A	647-V	urinary_tract	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60784	Target of Myb protein 1	DEG_SCF_FBW7_1	161:168	PIHTPQRT	FBXW7	0.9884	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons