DegronMD - O60784(TOM1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V169M	TCGA-EK-A2RL	CESC	TCGA	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.3056
p.L356P	TCGA-F5-6814	READ	TCGA	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.7582
p.L356M	TCGA-FI-A2D0	UCEC	TCGA	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.5999
p.E169Q	DO51906	BLCA	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.3056
p.A358T	DO48566	BLCA	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.3056
p.A350V	DO2842	BRCA	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.6936
p.L171V	DO222736	BTCA	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.A340V	DO234230	ESAD	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0833
p.R343Q	DO233898	GACA	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1667
p.S367I	DO10880	GBM	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0556
p.E158D	DO48582	KIRP	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.M159L	DO48582	KIRP	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.2778
p.D341N	DO26878	LUSC	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1111
p.S155R	DO42033	UCEC	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.1667
p.T172M	DO42985	UCEC	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.2222
p.R154C	DO41871	UCEC	ICGC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation blocking phosphorylation signal	0.5833
p.A358V	DO41199	UCEC	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.3056
p.R364Q	DO42633	UCEC	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1389
p.G345D	SIDM00465	Ovarian Carcinoma	GDSC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.2222
p.G345D	ACH-002183	Ovarian Cancer	CCLE	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.2222
p.G345D	OVMIU	ovary	COSMIC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.2222
p.P161L	SIDM00806	Osteosarcoma	GDSC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation altering degron motif	0.6471
p.P161L	HOS	bone	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation altering degron motif	0.6471
p.A363T	MZ7-mel	skin	COSMIC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1667
p.I158V	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.A155T	LoVo	large intestine	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.1667
p.I170V	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.2778
p.A167T	LoVo	large intestine	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation altering degron motif	0.7139
p.A351T	MZ7-mel	skin	COSMIC	VRAGLQSLE	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.6028
p.L153V	HT-1376	urinary tract	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.1111
p.L165V	HT-1376	urinary tract	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation altering degron motif	0.6765
p.D157A	647-V	urinary tract	COSMIC	PIHTPQRT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.2222

Kaplan plot for TOM1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOM1

UniProt ID: O60784

Entrez ID: 10043

Protein name: Target of Myb protein 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TOM1 in