DegronMD

Uniprot ID: O60784

Source protein: Target of Myb protein 1

Source gene: TOM1

Class: DEG_APCC_DBOX_1

Location: 349:357

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9945

ASA_SCORE: 89.8889

COIL: 0.6403

CONS_SCORE: 0.3665

DSS_SCORE: 0.3955

HELIX: 0.3383

FCONS_SCORE: 0.994

RIG_SCORE: 0.7113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L356P	TCGA-F5-6814	READ	TCGA	VRAGLQSLE	DEG_APCC_DBOX_1	0.7582
p.L356M	TCGA-FI-A2D0	UCEC	TCGA	VRAGLQSLE	DEG_APCC_DBOX_1	0.5999
p.A358T	DO48566	BLCA	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	0.3056
p.A350V	DO2842	BRCA	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	0.6936
p.A340V	DO234230	ESAD	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	0.0833
p.R343Q	DO233898	GACA	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	0.1667
p.S367I	DO10880	GBM	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	0.0556
p.D341N	DO26878	LUSC	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	0.1111
p.A358V	DO41199	UCEC	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	0.3056
p.R364Q	DO42633	UCEC	ICGC	VRAGLQSLE	DEG_APCC_DBOX_1	0.1389
p.G345D	SIDM00465	Ovarian Carcinoma	GDSC	VRAGLQSLE	DEG_APCC_DBOX_1	0.2222
p.G345D	ACH-002183	Ovarian Cancer	CCLE	VRAGLQSLE	DEG_APCC_DBOX_1	0.2222
p.G345D	OVMIU	ovary	COSMIC	VRAGLQSLE	DEG_APCC_DBOX_1	0.2222
p.A363T	MZ7-mel	skin	COSMIC	VRAGLQSLE	DEG_APCC_DBOX_1	0.1667
p.A351T	MZ7-mel	skin	COSMIC	VRAGLQSLE	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60784	Target of Myb protein 1	DEG_APCC_DBOX_1	349:357	VRAGLQSLE	APC,CDC20,FZR1	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons