DegronMD

Uniprot ID: Q8IZS6

Source protein: Dynein light chain Tctex-type protein 2

Source gene: DYNLT2

Class: DEG_SCF_FBW7_1

Location: 12:19

E3 ligase: FBXW7

DEGRON score: 0.9327

ASA_SCORE: 109.8625

COIL: 0.9395

CONS_SCORE: 0.2254

DSS_SCORE: 0.8569

HELIX: 0.0445

FCONS_SCORE: 0.7655

RIG_SCORE: 0.5823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R6L	TCGA-D3-A2JP	SKCM	TCGA	PIQTPNQT	DEG_SCF_FBW7_1	0.1667
p.R6L	DO47407	SKCM	ICGC	PIQTPNQT	DEG_SCF_FBW7_1	0.1667
p.Q18H	TCGA-XF-A8HF	BLCA	TCGA	PIQTPNQT	DEG_SCF_FBW7_1	0.647
p.Q18H	DO49800	BLCA	ICGC	PIQTPNQT	DEG_SCF_FBW7_1	0.647
p.Q18H	DO231772	LINC	ICGC	PIQTPNQT	DEG_SCF_FBW7_1	0.647
p.Q14H	DO220841	MELA	ICGC	PIQTPNQT	DEG_SCF_FBW7_1	0.647
p.Q14H	ACH-000997	Colon/Colorectal Cancer	CCLE	PIQTPNQT	DEG_SCF_FBW7_1	0.647
p.Q14H	HCT-15	large_intestine	COSMIC	PIQTPNQT	DEG_SCF_FBW7_1	0.647
p.K3Q	ACH-000427	Gastric Cancer	CCLE	PIQTPNQT	DEG_SCF_FBW7_1	0.1944
p.K3Q	NCI-N87	stomach	COSMIC	PIQTPNQT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZS6	Dynein light chain Tctex-type protein 2	DEG_SCF_FBW7_1	12:19	PIQTPNQT	FBXW7	0.9327	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons