DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 1507:1513

E3 ligase: FBXW7

DEGRON score: 0.6275

ASA_SCORE: 91.9143

COIL: 0.9459

CONS_SCORE: 0.3068

DSS_SCORE: 0.8135

HELIX: 0.0154

FCONS_SCORE: 1.0051

RIG_SCORE: 0.601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1501I	TCGA-D1-A103	UCEC	TCGA	PITPPAS	DEG_SCF_FBW7_1	0.1667
p.S1502T	DO6394	CLLE	ICGC	PITPPAS	DEG_SCF_FBW7_1	0.1944
p.T1504M	DO230659	LAML	ICGC	PITPPAS	DEG_SCF_FBW7_1	0.25
p.T1504M	DO49087	PACA	ICGC	PITPPAS	DEG_SCF_FBW7_1	0.25
p.T1504M	DO32819	PACA	ICGC	PITPPAS	DEG_SCF_FBW7_1	0.25
p.A1513T	DO229047	LICA	ICGC	PITPPAS	DEG_SCF_FBW7_1	0.7139
p.P1500S	DO220890	MELA	ICGC	PITPPAS	DEG_SCF_FBW7_1	0.1389
p.S1502I	DO42312	UCEC	ICGC	PITPPAS	DEG_SCF_FBW7_1	0.1944
p.P1510S	ACH-001610	Brain Cancer	CCLE	PITPPAS	DEG_SCF_FBW7_1	0.6752
p.P1500T	ACH-001685	Lymphoma	CCLE	PITPPAS	DEG_SCF_FBW7_1	0.1389
p.S1501T	ACH-001685	Lymphoma	CCLE	PITPPAS	DEG_SCF_FBW7_1	0.1667
p.S1501T	ACH-001844	Bile Duct Cancer	CCLE	PITPPAS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1507:1513	PITPPAS	FBXW7	0.6275	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons