DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4704:4710

E3 ligase: FBXW7

DEGRON score: 0.8893

ASA_SCORE: 100.6

COIL: 0.9261

CONS_SCORE: 0.2611

DSS_SCORE: 0.6412

HELIX: 0.0161

FCONS_SCORE: 0.9342

RIG_SCORE: 0.7485

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4709P	DO229010	COCA	ICGC	PITPVLT	DEG_SCF_FBW7_1	0.7031
p.T4709P	DO229013	COCA	ICGC	PITPVLT	DEG_SCF_FBW7_1	0.7031
p.T4709P	DO229016	COCA	ICGC	PITPVLT	DEG_SCF_FBW7_1	0.7031
p.T4709P	DO229003	COCA	ICGC	PITPVLT	DEG_SCF_FBW7_1	0.7031
p.T4709P	DO229005	COCA	ICGC	PITPVLT	DEG_SCF_FBW7_1	0.7031
p.T4709P	DO229346	LAML	ICGC	PITPVLT	DEG_SCF_FBW7_1	0.7031
p.T4715M	DO231140	LAML	ICGC	PITPVLT	DEG_SCF_FBW7_1	0.1944
p.T4715M	DO229047	LICA	ICGC	PITPVLT	DEG_SCF_FBW7_1	0.1944
p.T4694I	SIDM00216	Colorectal Carcinoma	GDSC	PITPVLT	DEG_SCF_FBW7_1	0.0556
p.T4694I	ACH-000989	Colon/Colorectal Cancer	CCLE	PITPVLT	DEG_SCF_FBW7_1	0.0556
p.I4705L	ACH-000801	Skin Cancer	CCLE	PITPVLT	DEG_SCF_FBW7_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4704:4710	PITPVLT	FBXW7	0.8893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons