DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SCF_FBW7_1

Location: 307:314

E3 ligase: FBXW7

DEGRON score: 0.9731

ASA_SCORE: 96.325

COIL: 0.9709

CONS_SCORE: 0.9875

DSS_SCORE: 0.7912

HELIX: 0.0101

FCONS_SCORE: 1.1313

RIG_SCORE: 0.5852

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P307Q	TCGA-43-2578	LUSC	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.7035
p.P307Q	DO26662	LUSC	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.7035
p.E302Q	TCGA-4Z-AA87	BLCA	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.1944
p.E302Q	DO218990	BLCA	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.1944
p.S297Y	TCGA-61-2104	OV	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.0556
p.S297Y	DO31849	OV	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.0556
p.E302D	TCGA-BS-A0TC	UCEC	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.1944
p.E302D	DO42400	UCEC	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.1944
p.S314F	TCGA-D3-A5GO	SKCM	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.7982
p.S314F	DO47419	SKCM	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.7982
p.P307L	TCGA-EB-A431	SKCM	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.6471
p.P307L	DO37671	SKCM	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.6471
p.S297F	TCGA-EE-A2GO	SKCM	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.0556
p.S297F	TCGA-EE-A2MR	SKCM	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.0556
p.S297F	DO37819	SKCM	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.0556
p.S297F	DO37823	SKCM	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.0556
p.S313F	TCGA-GF-A6C9	SKCM	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.6871
p.S313F	TCGA-GN-A8LK	SKCM	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.6871
p.S313F	DO229446	SKCA	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.6871
p.S313F	DO51254	SKCM	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.6871
p.S313F	DO51259	SKCM	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.6871
p.P307R	TCGA-RD-A7C1	STAD	TCGA	PITTPNSS	DEG_SCF_FBW7_1	0.7512
p.P307R	DO50132	STAD	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.7512
p.P298S	DO225336	BRCA	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.0833
p.I308N	DO233888	GACA	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.6169
p.S323P	DO228960	LICA	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.0833
p.T317A	DO50964	LICA	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.25
p.P307T	DO231043	LUSC	ICGC	PITTPNSS	DEG_SCF_FBW7_1	0.7031
p.D321N	SIDM01090	Colorectal Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00967	Ovarian Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00969	Ovarian Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00087	Plasma Cell Myeloma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00654	Small Cell Lung Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM01112	Osteosarcoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00650	Small Cell Lung Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00694	Other Solid Cancers	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00254	Neuroblastoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM01147	Gastric Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00539	Esophageal Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00807	Bladder Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM01133	Other Solid Cancers	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00930	Osteosarcoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM01681	Non-Cancerous	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389
p.D321N	SIDM01173	Rhabdomyosarcoma	GDSC	PITTPNSS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITTPNSS

Degron related mutations and impact score

Drug responses associated with MUC7 mutations

All proteins holding degron of PITTPNSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	307:314	PITTPNSS	FBXW7	0.9731	More...