DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 882:889

E3 ligase: FBXW7

DEGRON score: 0.991

ASA_SCORE: 105.2375

COIL: 0.9659

CONS_SCORE: 0.4018

DSS_SCORE: 0.6167

HELIX: 0.012

FCONS_SCORE: 1.4302

RIG_SCORE: 0.6275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E892Q	TCGA-CV-6961	HNSC	TCGA	PKETPTPS	DEG_SCF_FBW7_1	0.25
p.E875D	TCGA-CV-6961	HNSC	TCGA	PKETPTPS	DEG_SCF_FBW7_1	0.1389
p.E884D	DO228281	MALY	ICGC	PKETPTPS	DEG_SCF_FBW7_1	0.5647
p.S874P	DO36556	READ	ICGC	PKETPTPS	DEG_SCF_FBW7_1	0.1111
p.P896S	DO229465	SKCA	ICGC	PKETPTPS	DEG_SCF_FBW7_1	0.1389
p.P888S	DO50298	SKCM	ICGC	PKETPTPS	DEG_SCF_FBW7_1	0.5641
p.S874F	DO47320	SKCM	ICGC	PKETPTPS	DEG_SCF_FBW7_1	0.1111
p.P888H	DO41211	UCEC	ICGC	PKETPTPS	DEG_SCF_FBW7_1	0.6583
p.Q873R	SIDM02050	Colorectal Carcinoma	GDSC	PKETPTPS	DEG_SCF_FBW7_1	0.0833
p.M895V	SIDM01951	Colorectal Carcinoma	GDSC	PKETPTPS	DEG_SCF_FBW7_1	0.1667
p.E878Q	SIDM00892	Breast Carcinoma	GDSC	PKETPTPS	DEG_SCF_FBW7_1	0.2222
p.E878Q	BT-483	breast	COSMIC	PKETPTPS	DEG_SCF_FBW7_1	0.2222
p.P886A	ACH-002097	Skin Cancer	CCLE	PKETPTPS	DEG_SCF_FBW7_1	0.7503
p.P886A	CP66-MEL	skin	COSMIC	PKETPTPS	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	882:889	PKETPTPS	FBXW7	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons