DegronMD

Uniprot ID: Q6NZY4

Source protein: Zinc finger CCHC domain-containing protein 8

Source gene: ZCCHC8

Class: DEG_SCF_FBW7_1

Location: 489:496

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 87.6875

COIL: 0.9736

CONS_SCORE: 0.372

DSS_SCORE: 0.8354

HELIX: 0.0113

FCONS_SCORE: 1.2393

RIG_SCORE: 0.5485

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P494L	TCGA-IB-7651	PAAD	TCGA	PKGTPPLT	DEG_SCF_FBW7_1	0.6471
p.T505K	TCGA-PL-A8LZ	BRCA	TCGA	PKGTPPLT	DEG_SCF_FBW7_1	0.0833
p.V483I	NCI-H1155	lung	COSMIC	PKGTPPLT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NZY4	Zinc finger CCHC domain-containing protein 8	DEG_SCF_FBW7_1	489:496	PKGTPPLT	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons