DegronMD

Uniprot ID: P11168

Source protein: Solute carrier family 2, facilitated glucose transporter member 2

Source gene: SLC2A2

Class: DEG_SCF_FBW7_2

Location: 76:83

E3 ligase: FBXW7

DEGRON score: 0.9804

ASA_SCORE: 78.95

COIL: 0.7925

CONS_SCORE: 0.1872

DSS_SCORE: 0.3993

HELIX: 0.15

FCONS_SCORE: 1.329

RIG_SCORE: 0.7558

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A88E	TCGA-37-4130	LUSC	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.1944
p.A88E	DO229018	LICA	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.1944
p.A88E	DO26490	LUSC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.1944
p.S71L	TCGA-43-5670	LUSC	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.1944
p.S71L	DO26434	LUSC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.1944
p.S73T	TCGA-49-AARE	LUAD	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.25
p.S73T	DO218922	LUAD	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.25
p.N75K	TCGA-A5-A0G1	UCEC	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.3056
p.N75K	DO42472	UCEC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.3056
p.N75K	SIDM00683	Prostate Carcinoma	GDSC	PKPTPWAE	DEG_SCF_FBW7_2	0.3056
p.N75K	ACH-000977	lymph_node	CCLE	PKPTPWAE	DEG_SCF_FBW7_2	0.3056
p.N75K	LNCaP-Clone-FGC	prostate	COSMIC	PKPTPWAE	DEG_SCF_FBW7_2	0.3056
p.K77Q	TCGA-B5-A11H	UCEC	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.5833
p.K77Q	DO42825	UCEC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.5833
p.E85D	TCGA-D1-A16X	UCEC	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.2778
p.E85D	TCGA-VS-A8EJ	CESC	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.2778
p.E85D	DO51622	CESC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.2778
p.E85D	DO41799	UCEC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.2778
p.L92V	TCGA-DD-AAEI	LIHC	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.0833
p.L92V	DO219575	LIHC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.0833
p.I70L	TCGA-ES-A2HT	LIHC	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.1667
p.I70L	DO22956	LIHC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.1667
p.E83K	TCGA-IG-A5B8	ESCA	TCGA	PKPTPWAE	DEG_SCF_FBW7_2	0.7022
p.I70V	DO222947	BTCA	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.1667
p.I70V	SIDM01554	Mesothelioma	GDSC	PKPTPWAE	DEG_SCF_FBW7_2	0.1667
p.I70V	ACH-000331	Lung Cancer	CCLE	PKPTPWAE	DEG_SCF_FBW7_2	0.1667
p.Q91K	DO229027	LICA	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.1111
p.E85Q	DO224563	LUSC	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.2778
p.E66K	DO222710	MELA	ICGC	PKPTPWAE	DEG_SCF_FBW7_2	0.0556
p.Y72H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PKPTPWAE	DEG_SCF_FBW7_2	0.2222
p.Y72H	ACH-000922	Leukemia	CCLE	PKPTPWAE	DEG_SCF_FBW7_2	0.2222
p.Y72H	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	PKPTPWAE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKPTPWAE

Degron related mutations and impact score

Drug responses associated with SLC2A2 mutations

All proteins holding degron of PKPTPWAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11168	Solute carrier family 2, facilitated glucose transporter member 2	DEG_SCF_FBW7_2	76:83	PKPTPWAE	FBXW7	0.9804	More...