DegronMD

Uniprot ID: P28698

Source protein: Myeloid zinc finger 1

Source gene: MZF1

Class: DEG_SCF_FBW7_1

Location: 167:173

E3 ligase: FBXW7

DEGRON score: 0.9092

ASA_SCORE: 100.6714

COIL: 0.8793

CONS_SCORE: 0.4674

DSS_SCORE: 0.8968

HELIX: 0.0479

FCONS_SCORE: 1.0577

RIG_SCORE: 0.5523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E164Q	TCGA-08-0386	GBM	TCGA	PKTPPRT	DEG_SCF_FBW7_1	0.25
p.E164Q	DO13504	GBM	ICGC	PKTPPRT	DEG_SCF_FBW7_1	0.25
p.P171S	TCGA-AP-A1DK	UCEC	TCGA	PKTPPRT	DEG_SCF_FBW7_1	0.5641
p.P171S	DO42033	UCEC	ICGC	PKTPPRT	DEG_SCF_FBW7_1	0.5641
p.P161Q	TCGA-EE-A181	SKCM	TCGA	PKTPPRT	DEG_SCF_FBW7_1	0.1667
p.P161Q	DO37444	SKCM	ICGC	PKTPPRT	DEG_SCF_FBW7_1	0.1667
p.P165S	TCGA-EY-A215	UCEC	TCGA	PKTPPRT	DEG_SCF_FBW7_1	0.2778
p.P165S	DO42665	UCEC	ICGC	PKTPPRT	DEG_SCF_FBW7_1	0.2778
p.Q182K	DO229031	LICA	ICGC	PKTPPRT	DEG_SCF_FBW7_1	0.0833
p.T162S	SIDM00721	Small Cell Lung Carcinoma	GDSC	PKTPPRT	DEG_SCF_FBW7_1	0.6389
p.K168N	SIDM00959	Acute Myeloid Leukemia	GDSC	PKTPPRT	DEG_SCF_FBW7_1	0.5806
p.K168N	ACH-000641	Leukemia	CCLE	PKTPPRT	DEG_SCF_FBW7_1	0.5806
p.K168N	ACH-001036	Leukemia	CCLE	PKTPPRT	DEG_SCF_FBW7_1	0.5806
p.K168N	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPPRT	DEG_SCF_FBW7_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28698	Myeloid zinc finger 1	DEG_SCF_FBW7_1	167:173	PKTPPRT	FBXW7	0.9092	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons