DegronMD

Uniprot ID: Q14839

Source protein: Chromodomain-helicase-DNA-binding protein 4

Source gene: CHD4

Class: DEG_SCF_FBW7_1

Location: 1538:1544

E3 ligase: FBXW7

DEGRON score: 0.9972

ASA_SCORE: 80.4571

COIL: 0.9387

CONS_SCORE: 0.2589

DSS_SCORE: 0.8831

HELIX: 0.0204

FCONS_SCORE: 1.033

RIG_SCORE: 0.458

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1547V	TCGA-37-3789	LUSC	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.25
p.K1539E	TCGA-66-2777	LUSC	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.591
p.P1533L	TCGA-BA-4074	HNSC	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.1944
p.M1530I	TCGA-D3-A8GL	SKCM	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.1111
p.P1541L	TCGA-DA-A1I7	SKCM	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.7582
p.S1535L	TCGA-DD-A4NR	LIHC	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.6944
p.P1541A	TCGA-G2-A2EJ	BLCA	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.7503
p.P1543L	TCGA-HU-A4GC	STAD	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.6471
p.P1533T	TCGA-IB-7651	PAAD	TCGA	PKTPTPS	DEG_SCF_FBW7_1	0.1944
p.P1534A	DO554	BLCA	ICGC	PKTPTPS	DEG_SCF_FBW7_1	0.2222
p.V1550I	DO17492	KIRC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	0.1667
p.S1528L	DO44923	LIHC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	0.5
p.G1540V	DO26743	LUSC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	0.7532
p.K1532E	DO27516	LUSC	ICGC	PKTPTPS	DEG_SCF_FBW7_1	0.1667
p.P1534L	DO37951	SKCM	ICGC	PKTPTPS	DEG_SCF_FBW7_1	0.2222
p.P1536L	DO47797	STAD	ICGC	PKTPTPS	DEG_SCF_FBW7_1	0.2778
p.T1549M	SIDM02049	Pancreatic Carcinoma	GDSC	PKTPTPS	DEG_SCF_FBW7_1	0.6389
p.G1534R	SIDM00216	Colorectal Carcinoma	GDSC	PKTPTPS	DEG_SCF_FBW7_1	0.2222
p.G1534R	SNU-175	large_intestine	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.2222
p.K1529M	SIDM00285	Neuroblastoma	GDSC	PKTPTPS	DEG_SCF_FBW7_1	0.1944
p.K1529M	CHP-134	autonomic_ganglia	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.1944
p.P1541H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKTPTPS	DEG_SCF_FBW7_1	0.7694
p.P1541H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.7694
p.K1554M	ACH-001338	Neuroblastoma	CCLE	PKTPTPS	DEG_SCF_FBW7_1	0.0556
p.K1554M	CHP-134	autonomic_ganglia	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.0556
p.P1549H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.6389
p.K1537M	CHP-134	autonomic_ganglia	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.75
p.P1533H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.1944
p.P1528H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.5
p.P1534H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.2222
p.G1542R	SNU-175	large_intestine	COSMIC	PKTPTPS	DEG_SCF_FBW7_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKTPTPS

Degron related mutations and impact score

Drug responses associated with CHD4 mutations

All proteins holding degron of PKTPTPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14839	Chromodomain-helicase-DNA-binding protein 4	DEG_SCF_FBW7_1	1538:1544	PKTPTPS	FBXW7	0.9972	More...